Pauluzzi S, Merletti L
Boll Ist Sieroter Milan. 1977 Sep;56(4):310-5.
We tested the cyclophosphamide effects against the growth of adenovirus-transformed cells and the subsequent tumor development in the syngeneic host. Cyclophosphamide did not show any effect on the tumor evolution when injected 24 and 6 hours before cell implantation. Cyclophosphamide injected 24 or 39 hours after cell implantation prevented or retarded the tumor growth. In mice bearing palpable tumors, it induced their complete regression in 85,7% of the animals, but did not effect the development of the homograft immunity.
我们测试了环磷酰胺对同基因宿主中腺病毒转化细胞生长及随后肿瘤发展的影响。在细胞植入前24小时和6小时注射环磷酰胺时，对肿瘤进展没有任何影响。在细胞植入后24小时或39小时注射环磷酰胺可预防或延缓肿瘤生长。在患有可触及肿瘤的小鼠中，它使85.7%的动物肿瘤完全消退，但对同种移植免疫的发展没有影响。
