Bawa R, Nandu M
Bausch & Lomb, Rochester, NY 14692.
Biomaterials. 1990 Nov;11(9):724-8. doi: 10.1016/0142-9612(90)90035-o.
A silicone-based prepolymer was used as the major component for the fabrication of novel ocular devices. Gentamicin sulphate was used as a probe drug, due to its high aqueous solubility and widespread application. Mechanical properties of films containing the drug before and after gamma sterilization and exposure to heat were found to be unchanged. The hydrolytic stability of the polymer films was uncompromised by gamma sterilization. However, high pressure liquid chromatography analysis of the drug released from polymer matrices exposed to heat for long time periods indicated a small amount of degradation. The drug release rates of the devices were found to be affected by gamma irradiation and exposure to heat.
一种硅基预聚物被用作制造新型眼科器械的主要成分。硫酸庆大霉素因其高水溶性和广泛应用而被用作探针药物。含有该药物的薄膜在伽马灭菌和受热前后的机械性能未发生变化。聚合物薄膜的水解稳定性不受伽马灭菌的影响。然而，对长时间受热的聚合物基质释放的药物进行高压液相色谱分析表明有少量降解。发现这些器械的药物释放速率受伽马辐射和受热的影响。
