Peh S C, Looi L M, Wang F, Chua C T, Tan H W, Lam K L
Department of Pathology, Faculty of Medicine, University of Malaya, Kuala Lumpur.
Malays J Pathol. 1990 Jun;12(1):21-6.
In the 10-year period from October 1977 to July 1987, 149 cases of primary IgA nephropathy were histologically confirmed through renal biopsies in the Department of Pathology, University Hospital, Kuala Lumpur. The ages of these patients ranged from 5 to 72 years, with the majority in the 20-30 year age group. There was no sex preponderance. The ethnic distribution showed a significant predominance of Chinese with 107 (71.8%) Chinese, 24 (16.1%) Malays, 15 (10.1%) Indians and 3 others. A wide range of renal glomerular pathology was seen, the commonest being diffuse mesangioproliferative glomerulonephritis (59.1%). Focal proliferative glomerulonephritis (14.1%) followed by minimal change glomerulonephritis (10.7%) were next in order of frequency. Immunofluorescence studies consistently demonstrated heavy and predominant IgA deposition in the mesangium. Weak deposition of C3, IgG and IgM were also observed in various combinations.
在1977年10月至1987年7月的10年期间，吉隆坡大学医院病理科通过肾活检组织学确诊了149例原发性IgA肾病。这些患者的年龄在5岁至72岁之间，大多数在20至30岁年龄组。没有性别优势。种族分布显示，华人占显著多数，其中华人107例（71.8%），马来人24例（16.1%），印度人15例（10.1%），其他3例。可见广泛的肾小球病理改变，最常见的是弥漫性系膜增生性肾小球肾炎（59.1%）。局灶性增生性肾小球肾炎（14.1%）其次是微小病变性肾小球肾炎（10.7%），按频率排列居次。免疫荧光研究一致显示系膜中有大量且主要的IgA沉积。还观察到C3、IgG和IgM以各种组合方式出现弱阳性沉积。
