Frank R, Tonet J, Rougier I, Gallais Y, Fontaine G, Grosgogeat Y
Hospital Jean Rostand, Ivry, Francia.
Arch Inst Cardiol Mex. 1990 Sep-Oct;60(5):491-7.
Between 1983 and 1989, 69 patients underwent endocardial fulguration for drug-resistant VT which had several relapses per month, or were incessant. The etiologies were an old myocardial infarction, (25 cases) arrhythmogenic right ventricular dysplasia, (19 cases) dilated cardiomyocathy, (9 cases) left fascicular tachycardia, (9 cases) 5 right septal idiopathic tachycardia, and 2 congenital heart disease. The ejection fraction ranged between 12 and 30% in 25 cases. VT originated in 32 patients in the right ventricle, 31 in the left, and 6 had fulguration in both ventricles. 41 patients had 1 session, 22 needed 2, 4 had three sessions and 2 had 4. Five patients died during the procedure, four of low output, and three of them before the shocks. One died of tamponade. Two others had tamponade and were successfully drained. Four patients died during the first 3 months of preexisting heart failure without VT relapse. The remaining patients have a mean follow-up of 32 months, ranging from 3 to 72 months. 32 patients are off drug and had no relapse. 23 had early relapses, and are controlled by previously ineffective drugs. However 3 of these had a late sudden death (4, 14 and 22 months). 9 are treated with a combination of drug not tested before. The success rate ranges from 60% in septal VT to 74% in ARVD, 86% in MI and 100% in idiopathic left fascicular VT. The success rate increases with the number of sessiones. Fulguration alone, or combined with pharmacological agents can be considered as an effective therapy for VT, despite that it is neither simple, nor harmless.
1983年至1989年间,69例患者因耐药性室性心动过速(VT)接受心内膜电灼术,这些患者每月有多次复发,或呈持续性发作。病因包括陈旧性心肌梗死(25例)、致心律失常性右室发育不良(19例)、扩张型心肌病(9例)、左束支性心动过速(9例)、5例右间隔特发性心动过速以及2例先天性心脏病。25例患者的射血分数在12%至30%之间。室性心动过速起源于右心室的有32例患者,起源于左心室的有31例,6例在双侧心室进行了电灼。41例患者进行了1次治疗,22例需要2次,4例需要3次,2例需要4次。5例患者在手术过程中死亡,4例死于低心输出量,其中3例在电击前死亡。1例死于心包填塞。另外2例发生心包填塞,但成功引流。4例患者在原有心力衰竭的前3个月内死亡,未出现室性心动过速复发。其余患者平均随访32个月,范围为3至72个月。32例患者停用药物且未复发。23例早期复发,现由之前无效的药物控制。然而,其中3例发生晚期猝死(分别在4、14和22个月)。9例患者采用之前未测试过的药物联合治疗。成功率范围从间隔性室性心动过速的60%到致心律失常性右室发育不良的74%、心肌梗死的86%以及特发性左束支性室性心动过速的100%。成功率随治疗次数增加。尽管心内膜电灼术既不简单也并非无害,但单独使用或与药物联合使用可被视为室性心动过速的有效治疗方法。