[Interrelationship between the restructuring of liver microvessel endothelium and changes in Kupffer's cells and hepatocytes in the development of gram-negative infection].

The morphological study of various types of liver cells revealed early reaction of sinusoid endothelial cells during the development of gram-negative infection (Salmonella typhimurium). The reaction of sinusoid endothelial cells is obviously connected with the direct effect of endotoxin because the first increase of endotoxin level in the blood is detected 60 min after injection of bacteria. The initial signs of Kupffer's cell activation are revealed at the same time. One of the manifestations of endothelial cell reaction is the increase of porosity of the barrier between the blood and Disse's space. It is accompanied by ultrastructural changes in hepatocytes. The second sharp rise of endotoxin level occurs 24 hours after the administration of bacteria and is accompanied by necrobiotic changes in the endothelial cells. It is assumed that the intensity of sinusoidal endothelial cell reaction and Kupffer's cell activation determine the degree of liver damage during the development of infection.