在低细胞外钙溶液中神经冲动对自发递质释放的抑制作用。
Quelling of spontaneous transmitter release by nerve impulses in low extracellular calcium solutions.
作者信息
Erulkar S D, Rahamimoff R, Rotshenker S
出版信息
J Physiol. 1978 May;278:491-500. doi: 10.1113/jphysiol.1978.sp012319.
Abstract
- The effect of nerve stimulation on spontaneous transmitter release was studied at the frog neuromuscular synapse which was bathed in a solution containing very low extracellular calcium concentration. Conventional methods for intracellular and extracellular recording were used and the pattern of quantal liberation following the nerve stimulus was determined. 2. Stimulation of the motor nerve (at rates between 0.09 and 2Hz) caused a reduction in the frequency of the miniature e.p.p.s in comparison to the prestimulation values. 3. The mean distribution of the time of occurrence of the miniature e.p.p.s during the interstimulus period showed periodic oscillations. 4. The quelling effect of nerve stimulation on transmitter release is explained by the hypothesis that a low [Ca]o a reversed electrochemical gradient for calcium occurs and nerve stimulation causes an increased calcium conductance leading to calcium efflux which in turn temporarily reduces [Ca]i and transmitter release.
摘要
- 在蛙神经肌肉突触处研究了神经刺激对自发递质释放的影响，该突触浸泡在细胞外钙浓度极低的溶液中。采用传统的细胞内和细胞外记录方法，并确定了神经刺激后量子释放的模式。2. 与刺激前的值相比，刺激运动神经（频率在0.09至2Hz之间）导致微小终板电位的频率降低。3. 在刺激间期，微小终板电位出现时间的平均分布显示出周期性振荡。4. 神经刺激对递质释放的抑制作用可通过以下假设来解释：低细胞外钙浓度导致钙的电化学梯度逆转，神经刺激导致钙电导增加，进而引起钙外流，这反过来又暂时降低了细胞内钙浓度和递质释放。
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