小龙虾神经肌肉接头处诱发和自发递质释放的强直后衰减以及突触易化的残余钙模型。
Post-tetanic decay of evoked and spontaneous transmitter release and a residual-calcium model of synaptic facilitation at crayfish neuromuscular junctions.
作者信息
Zucker R S, Lara-Estrella L O
出版信息
J Gen Physiol. 1983 Mar;81(3):355-72. doi: 10.1085/jgp.81.3.355.
Abstract
The post-tetanic decay in miniature excitatory junction potential (MEJP) frequency and in facilitation of excitatory junction potentials (EJPs) was measured at crayfish neuromuscular junctions. A 2-s tetanus at 20 Hz caused the MEJP frequency to increase an average of 40 times and the EJP amplitude to increase an average of 13 times. Both MEJP frequency and EJP facilitation decayed with two time constants. The fast component of MEJP frequency decay was 47 ms, and that of EJP facilitation was 130 ms. The slow component of MEJP frequency decay was 0.57 s, and that of EJP facilitation was approximately 1 s. These results were consistent with the predictions of a residual calcium model, with a nonlinear relationship between presynaptic calcium concentration and transmitter release.
摘要
在小龙虾神经肌肉接头处测量了微小兴奋性突触后电位（MEJP）频率的强直后衰减以及兴奋性突触后电位（EJP）的易化情况。以20 Hz进行2秒的强直刺激使MEJP频率平均增加40倍，EJP幅度平均增加13倍。MEJP频率和EJP易化均以两个时间常数衰减。MEJP频率衰减的快速成分是47毫秒，EJP易化的快速成分是130毫秒。MEJP频率衰减的慢速成分是0.57秒，EJP易化的慢速成分约为1秒。这些结果与残余钙模型的预测一致，即突触前钙浓度与递质释放之间存在非线性关系。
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