四氧嘧啶糖尿病兔的脂蛋白组成

Lipoprotein composition in the alloxan-diabetic rabbit.

作者信息

O'Meara N M, O'Donnell L J, Owens D, Collins P B, Johnson A H, Tomkin G H

机构信息

Department of Biochemistry, Royal College of Surgeons, Ireland, Dublin.

出版信息

Diabetes Res. 1990 Feb;13(2):89-94.

PMID:2091875

Abstract

This study investigates the lipoprotein abnormalities in the alloxan-diabetic rabbit maintained on a standard chow diet. Poorly-controlled diabetic rabbits had elevated levels of triglyceride and phospholipid (reflected in all lipoprotein fractions) and cholesterol (reflected in the very low density and high density lipoprotein fractions) compared with well-controlled and non-diabetic rabbits. The importance of diabetic control in these changes was emphasized by the observation of a positive correlation between weight loss and serum triglyceride (rs = 0.62, p less than 0.02), cholesterol (rs = 0.65, p less than 0.01) and phospholipid (rs = 0.56, p less than 0.05). The lipoprotein fractions of the poorly-controlled rabbits were enriched with triglyceride.

摘要

本研究调查了以标准饲料喂养的四氧嘧啶糖尿病兔的脂蛋白异常情况。与血糖控制良好的兔和非糖尿病兔相比，血糖控制不佳的糖尿病兔甘油三酯和磷脂水平升高（反映在所有脂蛋白组分中），胆固醇水平升高（反映在极低密度脂蛋白和高密度脂蛋白组分中）。体重减轻与血清甘油三酯（rs = 0.62，p < 0.02）、胆固醇（rs = 0.65，p < 0.01）和磷脂（rs = 0.56，p < 0.05）之间呈正相关，这一观察结果强调了糖尿病控制在这些变化中的重要性。血糖控制不佳的兔的脂蛋白组分富含甘油三酯。