Serum total cholesterol, triglycerides and high density lipoproteins (HDL) levels in rabbit during the course of experimental diabetes.

The study was conducted on 56 rabbits, of White New Zealand breed, male gender. The average weight of the rabbits was 3 kg. The diabetes was evoked by intravenous injection of 10% alloxan, using the single dose of 100 mg/kg. On the 7th day after administration of alloxan, serum glucose levels were determined. The serum glucose level higher than 11.1 mmol/l was considered an indicator of the presence of diabetes. All the animals included in the study were divided into five groups: the control, 21-day diabetes, 42-day diabetes, 90-day diabetes and 180-day diabetes. Serum total cholesterol, triglycerides and high density lipoproteins levels were determined with enzymatic methods. Our studies revealed a significant increase in cholesterol and triglycerides levels. That mechanism might be responsible for faster development of atheromatosis during the course of diabetes mellitus.