Lizarazo-Barrera Juan Carlos, Jacobelli Sergio, Mellado Patricio, González Sergio, Massardo Loreto
Departamento de Inmunología Clínica y Reumatología, Facultad de Medicina Pontificia Universidad Católica de Chile, Santiago de Chile.
Rev Med Chil. 2010 Jun;138(6):746-51. doi: 10.4067/s0034-98872010000600013.
Behçet's disease (BD) is a systemic inflammatory vascular disease with several clinical manifestations and geographical differences in disease expression. In Middle Eastern countries it is one of the most common causes of cerebral venous thrombosis. We report a 29-year-old female admitted for acute headache and vomiting. A magnetic resonance image showed a large thrombosis of sagital and transverse sinuses. She developed oral and genital ulcers a week later. Ophthalmologic examination revealed left anterior uveitis and ipsilateral papilledema. Multiple studies ruled out a hypercoagulability syndrome. The patient used oral contraceptives. Anticoagulant therapy was prescribed. A biopsy of a genital ulcer demonstrated diffuse lymphocytic infiltration with vasculitis. After treatment with topical and systemic corticoids, her condition improved. Venous sinus thrombosis followed by oral and genital ulcers is an unusual presentation of Behçet's disease.
白塞病（BD）是一种全身性炎症性血管疾病，有多种临床表现，且疾病表现存在地域差异。在中东国家，它是脑静脉血栓形成最常见的原因之一。我们报告一名29岁女性因急性头痛和呕吐入院。磁共振成像显示矢状窦和横窦有大面积血栓形成。一周后她出现口腔和生殖器溃疡。眼科检查发现左眼前葡萄膜炎和同侧视乳头水肿。多项检查排除了高凝综合征。该患者使用口服避孕药。给予抗凝治疗。生殖器溃疡活检显示弥漫性淋巴细胞浸润伴血管炎。经局部和全身使用皮质类固醇治疗后，她的病情有所改善。静脉窦血栓形成后出现口腔和生殖器溃疡是白塞病的一种不寻常表现。
