“顺其自然”：Krüppel 样因子 2 如何调节切应力的血管保护作用。
"Go with the flow": how Krüppel-like factor 2 regulates the vasoprotective effects of shear stress.
机构信息
Division of Hematology/Oncology, Department of Medicine, Case Western Reserve University School of Medicine, University Hospitals, Case Western Reserve University, Cleveland, Ohio 44106, USA.
出版信息
Antioxid Redox Signal. 2011 Sep 1;15(5):1449-61. doi: 10.1089/ars.2010.3647. Epub 2011 Apr 15.
Abstract
Laminar shear stress is known to confer potent anti-inflammatory, antithrombotic, and antiadhesive effects by differentially regulating endothelial gene expression. The identification of Krüppel-like factor 2 as a flow-responsive molecule has greatly advanced our understanding of molecular mechanisms governing vascular homeostasis. This review summarizes the current understanding of Krüppel-like factor 2 action in endothelial gene expression and function.
摘要
层流切应力通过差异调节内皮基因表达，从而发挥强大的抗炎、抗血栓和抗黏附作用。Krüppel 样因子 2 作为一种对流动有反应的分子被发现，这极大地促进了我们对血管稳态调控的分子机制的理解。本文总结了 Krüppel 样因子 2 在内皮基因表达和功能中的作用的现有认识。
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Proc Natl Acad Sci U S A. 2010 Apr 13;107(15):6858-63. doi: 10.1073/pnas.1000444107. Epub 2010 Mar 29.
2
Kruppel-like factor 4 (Klf4) prevents embryonic stem (ES) cell differentiation by regulating Nanog gene expression.Kruppel 样因子 4（Klf4）通过调节 Nanog 基因的表达来防止胚胎干细胞（ES 细胞）分化。
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3
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4
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6
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9
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10
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J Biol Chem. 2009 Jul 10;284(28):18882-92. doi: 10.1074/jbc.M109.009886. Epub 2009 May 19.
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