Division of Hematology/Oncology, Department of Medicine, Case Western Reserve University School of Medicine, University Hospitals, Case Western Reserve University, Cleveland, Ohio 44106, USA.
Antioxid Redox Signal. 2011 Sep 1;15(5):1449-61. doi: 10.1089/ars.2010.3647. Epub 2011 Apr 15.
Laminar shear stress is known to confer potent anti-inflammatory, antithrombotic, and antiadhesive effects by differentially regulating endothelial gene expression. The identification of Krüppel-like factor 2 as a flow-responsive molecule has greatly advanced our understanding of molecular mechanisms governing vascular homeostasis. This review summarizes the current understanding of Krüppel-like factor 2 action in endothelial gene expression and function.
层流切应力通过差异调节内皮基因表达，从而发挥强大的抗炎、抗血栓和抗黏附作用。Krüppel 样因子 2 作为一种对流动有反应的分子被发现，这极大地促进了我们对血管稳态调控的分子机制的理解。本文总结了 Krüppel 样因子 2 在内皮基因表达和功能中的作用的现有认识。
