Bhatia A
Department of Pathology, University College of Medical Sciences, Shahdara, Delhi.
Indian J Pathol Microbiol. 1990 Jul;33(3):221-3.
30 male albino rats of Wistar strain were used to study the effect of repeated administration of small doses of paracetamol over a period of 24 weeks. The animals were administered 0.3 g of paracetamol orally admixed in the diet, after an overnight fast. Three animals from the test group and one control were sacrificed at the end of 4, 8, 12, 16, 20 and 24 weeks, under ether anaesthesia. Liver cell necrosis was not seen at any stage of the experiment. Fatty change was focal at 4 to 8 weeks and diffuse at 12 to 24 weeks. Chronic administration of paracetamol admixed in the diet showed less extensive changes comprising of focal ballooning degeneration. Ultrastructural changes involved mitochondria and RER. Fibrosis was not seen.
选用30只Wistar品系雄性白化病大鼠，研究连续24周小剂量服用对乙酰氨基酚的影响。动物在禁食过夜后，经口给予混于饮食中的0.3克对乙酰氨基酚。在第4、8、12、16、20和24周结束时，在乙醚麻醉下处死试验组的3只动物和1只对照组动物。在实验的任何阶段均未观察到肝细胞坏死。脂肪变在4至8周时为局灶性，在12至24周时为弥漫性。饮食中混有对乙酰氨基酚的长期给药显示出程度较轻的变化，包括局灶性气球样变性。超微结构变化涉及线粒体和粗面内质网。未观察到纤维化。
