Rosa H, Prudente M S, Cardoso V M
Arq Gastroenterol. 1984 Oct-Dec;21(4):164-6.
The aim of this study was to test the effect of cholestyramine on the hepatotoxic reactions due to paracetamol overdose. Wistar rats receiving a 5% aqueous solution of paracetamol at a dose of 750 mg/kg intraperitoneally showed a extensive necrosis within 24 hrs, whereas the addition of 4% cholestyramine to the diet inhibited the hepatic aggression. The protective mechanisms of cholestyramine against paracetamol overdose were admitted to be identical to those observed in the inhibition of liver cirrhosis induced by CCl4. The authors' hypothesis is that the paracetamol aggression and cholestyramine protection are both bile salts related.
本研究的目的是测试消胆胺对乙酰氨基酚过量所致肝毒性反应的影响。给Wistar大鼠腹腔注射剂量为750mg/kg的5%乙酰氨基酚水溶液，24小时内出现广泛坏死，而在饮食中添加4%消胆胺可抑制肝脏损伤。消胆胺对乙酰氨基酚过量的保护机制被认为与抑制四氯化碳诱导的肝硬化中观察到的机制相同。作者的假设是，乙酰氨基酚的损伤作用和消胆胺的保护作用均与胆盐有关。
