Department of General Surgery, Yuzuncu Yıl University Medical Faculty, Van, Turkey.
World J Surg Oncol. 2010 Sep 28;8:85. doi: 10.1186/1477-7819-8-85.
Acute-phase response proteins (APRP), cytokines and hormones have been claimed to be an independent prognostic factor of malignancies, however the basis for their association with prognosis remains unexplained. We suggest that in colon malignancies, as similar to pancreatic and lung cancers, changes in APRP are associated with angiogenesis.
C-reactive protein (CRP), albumin, IL-1α, IL-1β, IL-6, IL-8, IL-10, TNF-α, midkine, VEGF-A, VEGF-C, leptin, adiponectin, and ghrelin serum levels are studied in 126 colon cancer patients and 36 healthy subjects.
We found statistically significant difference and correlations between two groups. We found significantly higher serum CRP, IL-1α, IL-1β, IL-6, IL-8, IL-10, TNF-α, VEGF-A, VEGF-C and leptin concentrations in patients relative to controls (p < 0.001). We found lower levels of the serum albumin, midkine, adiponectin and ghrelin in patients compared to control subjects (p < 0.001).
Cachexia in patients with colon cancers is associated with changes in APRP, cytokines and hormone concentrations. These biomarkers and cachexia together have a direct relationship with accelerated angiogenesis. This may lead to a connection between the outcomes in malignancies and the biomarkers.
急性期反应蛋白（APRP）、细胞因子和激素被认为是恶性肿瘤的独立预后因素，但它们与预后相关的基础仍未得到解释。我们认为，在结肠癌中，与胰腺癌和肺癌类似，APRP 的变化与血管生成有关。
在 126 例结肠癌患者和 36 例健康对照者中，研究了 C 反应蛋白（CRP）、白蛋白、IL-1α、IL-1β、IL-6、IL-8、IL-10、TNF-α、中期因子、VEGF-A、VEGF-C、瘦素、脂联素和 ghrelin 血清水平。
我们发现两组之间存在统计学显著差异和相关性。与对照组相比，患者血清 CRP、IL-1α、IL-1β、IL-6、IL-8、IL-10、TNF-α、VEGF-A、VEGF-C 和瘦素浓度显著升高（p < 0.001）。与对照组相比，患者血清白蛋白、中期因子、脂联素和 ghrelin 水平较低（p < 0.001）。
结肠癌患者的恶病质与 APRP、细胞因子和激素浓度的变化有关。这些生物标志物和恶病质与加速血管生成直接相关。这可能导致恶性肿瘤的结果与生物标志物之间存在联系。
