Urup Thomas, Madsen Gitte, Hallager Sofie, Schmitz Alexander, Fogd Kirsten, Bøgsted Martin, Nyegaard Mette, Sørensen Karen Dybkaer, Johnsen Hans E
Århus Universitetshospital, Aalborg Sygehus, Haematologisk Afdeling, Denmark.
Ugeskr Laeger. 2010 Sep 20;172(38):2597-600.
Cancer is dependent on so-called cancer stem cells that initiate and maintain the cancer cell population. Stem cells are described in normal tissue as low-frequent, self-renewing cells with a multi- or pluripotent differentiation potential. The true characteristics of the cancer-initiating cells are still not entirely known, but it is obvious that identifying these cells will enable us to better understand the biology of cancer. In this article, we focus on normal haematopoietic stem cells and cancer stem cells in leukaemia and multiple myeloma.
癌症依赖于所谓的癌症干细胞，这些干细胞启动并维持癌细胞群体。在正常组织中，干细胞被描述为低频率、自我更新的细胞，具有多能或全能分化潜能。癌症起始细胞的真正特征仍不完全清楚，但很明显，识别这些细胞将使我们能够更好地理解癌症生物学。在本文中，我们重点关注白血病和多发性骨髓瘤中的正常造血干细胞和癌症干细胞。
