对《肿瘤生长未必由罕见的癌症干细胞驱动》的评论

Comment on "Tumor growth need not be driven by rare cancer stem cells".

作者信息

Kennedy James A, Barabé Frédéric, Poeppl Armando G, Wang Jean C Y, Dick John E

机构信息

Division of Cell and Molecular Biology, University Health Network, Toronto, Canada.

出版信息

Science. 2007 Dec 14;318(5857):1722; author reply 1722. doi: 10.1126/science.1149590.

DOI:10.1126/science.1149590

PMID:18079385

Abstract

Kelly et al. (Brevia, 20 July 2007, p. 337) questioned xenotransplant experiments supporting the cancer stem cell (CSC) hypothesis because they found a high frequency of leukemia-initiating cells (L-IC) in some transgenic mouse models. However, the CSC hypothesis depends on prospective purification of cells with tumor-initiating capacity, irrespective of frequency. Moreover, we found similar L-IC frequencies in genetically comparable leukemias using syngeneic or xenogeneic models.

摘要

凯利等人（《简报》，2007年7月20日，第337页）对支持癌症干细胞（CSC）假说的异种移植实验提出质疑，因为他们在一些转基因小鼠模型中发现了高频率的白血病起始细胞（L-IC）。然而，CSC假说依赖于对具有肿瘤起始能力的细胞进行前瞻性纯化，而不考虑频率。此外，我们在使用同基因或异种基因模型的基因可比白血病中发现了相似的L-IC频率。