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成人心房颤动的年发生率及相关因素。

Annual incidence of atrial fibrillation and related factors in adults.

机构信息

Department of Stroke Medicine, Kawasaki Medical School, Kurashiki, Japan.

出版信息

Am J Cardiol. 2010 Oct 15;106(8):1129-33. doi: 10.1016/j.amjcard.2010.06.030.

Abstract

The aim of this study was to investigate the annual incidence of atrial fibrillation (AF) and related factors from health surveys in 2006 and 2007. Participants (aged ≥ 40 years) were examined from annual health surveys provided by the Kurashiki Public Health Center twice, in 2006 and 2007. Participants were classified into 2 groups: a control group without AF in 2006 and 2007, and an AF group with documented AF in 2007 but not in 2006. Annual AF incidence (per 1,000 patient-years) was calculated, and baseline characteristics were compared between groups. Independent factors for new documented AF were analyzed using multivariate logistic regression modeling. Health surveys were performed for 30,449 participants in 2006 and 2007. Excluding 439 participants with AF in 2006, newly documented AF was observed in 278 participants (0.9%), while the control group comprised 29,732 participants. The overall incidence of newly documented AF was 9.3/1,000 patient-years. Newly documented AF was significantly associated with age ≥ 80 years (odds ratio [OR] 1.57, 95% confidence interval [CI] 1.20 to 2.06, p = 0.001), history of cardiac disease (OR 7.47, 95% CI 5.79 to 9.63, p < 0.001), increasing estimated glomerular filtration rate of 10 ml/min/1.73 m(2) (OR 0.93, 95% CI 0.87 to 0.99, p = 0.025), and hypercholesterolemia (OR 0.75, 95% CI 0.58 to 0.96, p = 0.023).

摘要

本研究旨在调查 2006 年和 2007 年健康调查中房颤(AF)的年发病率及相关因素。参与者(年龄≥40 岁)来自 2006 年和 2007 年两次由仓敷公共卫生中心提供的年度健康调查。将参与者分为两组:2006 年和 2007 年均无房颤的对照组,以及 2007 年有记录的房颤但 2006 年无房颤的房颤组。计算每年房颤发病率(每 1000 例患者年),并比较两组间的基线特征。采用多变量逻辑回归模型分析新诊断房颤的独立因素。2006 年和 2007 年共对 30449 名参与者进行了健康调查。排除 2006 年有房颤的 439 名参与者后,278 名参与者(0.9%)新诊断为房颤,而对照组包括 29732 名参与者。新诊断房颤的总发生率为 9.3/1000 例患者年。新诊断房颤与年龄≥80 岁(比值比 [OR] 1.57,95%置信区间 [CI] 1.20 至 2.06,p=0.001)、心脏病史(OR 7.47,95% CI 5.79 至 9.63,p<0.001)、估计肾小球滤过率增加 10 ml/min/1.73 m(2)(OR 0.93,95% CI 0.87 至 0.99,p=0.025)和高胆固醇血症(OR 0.75,95% CI 0.58 至 0.96,p=0.023)显著相关。

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