小分子离子通道配对：新型 ASIC 配体的天然选择。
Small molecule ion channel match making: a natural fit for new ASIC ligands.
机构信息
Cardiovascular Research Institute, University of California, San Francisco, San Francisco, California 94158-2330, USA.
出版信息
Neuron. 2010 Oct 6;68(1):1-3. doi: 10.1016/j.neuron.2010.09.038.
Abstract
ASICs (acid-sensing ion channels) are proton-gated channels that are important for pain sensation. New work by Yu and coworkers in this issue of Neuron identifies synthetic ligands and related small molecules found in the inflammatory soup that activate ASICs. These new findings highlight the power of small molecule screening to find new compounds that can control channel function. They also demonstrate how the discovery and characterization of such molecules can lead to new insights regarding channel mechanism and natural ligands.
摘要
ASICs（酸感应离子通道）是质子门控通道，对于痛觉很重要。神经元杂志本期中由 Yu 和同事们开展的新工作鉴定了在炎症汤中发现的激活 ASICs 的合成配体和相关的小分子。这些新发现突出了小分子筛选寻找可控制通道功能的新化合物的力量。它们还表明，此类分子的发现和表征如何能够为通道机制和天然配体提供新的见解。
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本文引用的文献
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A nonproton ligand sensor in the acid-sensing ion channel.酸敏离子通道中的非质子配体传感器。
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ASIC3, a sensor of acidic and primary inflammatory pain.酸敏感离子通道蛋白3（ASIC3），一种酸性和原发性炎性疼痛的感受器。
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Structure of acid-sensing ion channel 1 at 1.9 A resolution and low pH.酸敏感离子通道1在1.9埃分辨率和低pH值下的结构
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A tarantula peptide against pain via ASIC1a channels and opioid mechanisms.一种通过酸敏感离子通道1a（ASIC1a）和阿片类机制发挥止痛作用的狼蛛肽
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10
A conformation change in the extracellular domain that accompanies desensitization of acid-sensing ion channel (ASIC) 3.伴随着酸敏感离子通道（ASIC）3脱敏的细胞外结构域构象变化。
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