酸敏感离子通道：疼痛与中枢神经系统疾病的新靶点。
Acid-sensing ion channels: A new target for pain and CNS diseases.
作者信息
Sluka Kathleen A, Winter Olivia C, Wemmie John A
机构信息
University of Iowa, Iowa City, 52242, USA.
出版信息
Curr Opin Drug Discov Devel. 2009 Sep;12(5):693-704.
Abstract
Low pH in tissue can evoke pain in animals and humans, and is an important factor in hyperalgesia. Research has also implicated acidosis in psychiatric and neurological diseases. One emerging class of pH-detecting receptors is that of the acid-sensing ion channels (ASICs). Advances in ASIC research have improved the understanding of the role played by pH dynamics in physiological and pathophysiological processes. Increasing evidence suggests that targeting ASICs with pharmacological agents may offer an effective and novel approach for treating pain and diseases of the CNS. However, the development of pharmaceuticals that target ASICs and are suitable for clinical use remains an obstacle. This review provides an update on ASICs and their potential for therapeutic modification in pain and CNS diseases.
摘要
组织中的低pH值可引起动物和人类疼痛，是痛觉过敏的一个重要因素。研究还表明酸中毒与精神和神经疾病有关。一类新兴的pH检测受体是酸敏感离子通道（ASICs）。ASIC研究的进展增进了人们对pH动态变化在生理和病理生理过程中所起作用的理解。越来越多的证据表明，用药物靶向ASICs可能为治疗疼痛和中枢神经系统疾病提供一种有效且新颖的方法。然而，开发靶向ASICs且适用于临床的药物仍然是一个障碍。本综述提供了关于ASICs及其在疼痛和中枢神经系统疾病治疗性修饰方面潜力的最新信息。
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