杏仁核体积与颞叶癫痫的性别无关。
Absence of gender effect on amygdala volume in temporal lobe epilepsy.
机构信息
Gynecology Department, Universidade Federal de São Paulo, São Paulo, Brazil.
出版信息
Epilepsy Behav. 2010 Nov;19(3):501-3. doi: 10.1016/j.yebeh.2010.08.031.
Sexual dimorphism has already been described in temporal lobe epilepsy with mesial temporal sclerosis (TLE-MTS). This study evaluated the effect of gender on amygdala volume in patients with TLE-MTS. One hundred twenty-four patients with refractory unilateral or bilateral TLE-MTS who were being considered for epilepsy surgery underwent a comprehensive presurgical evaluation and MRI. Amygdalas of 67 women (27 with right; 32 with left, and 8 with bilateral TLE) and 57 men (22 with right, 30 with left, and 5 with bilateral TLE) were manually segmented. Significant ipsilateral amygdala volume reduction was observed for patients with right and left TLE. No gender effect on amygdala volume was observed. Contralateral amygdalar asymmetry was observed for patients with right and left TLE. Although no gender effect was observed on amygdala volume, ipsilateral amygdala volume reductions in patients with TLE might be related to differential rates of cerebral maturation between hemispheres.
性别二态性在伴有海马硬化的颞叶癫痫（TLE-MTS）中已经得到描述。本研究评估了性别对 TLE-MTS 患者杏仁核体积的影响。124 例接受难治性单侧或双侧 TLE-MTS 癫痫手术评估的患者接受了全面的术前评估和 MRI。对 67 名女性（27 名右侧，32 名左侧，8 名双侧）和 57 名男性（22 名右侧，30 名左侧，5 名双侧）的杏仁核进行手动分割。右侧和左侧 TLE 患者的同侧杏仁核体积明显减少。未观察到性别对杏仁核体积的影响。右侧和左侧 TLE 患者的对侧杏仁核不对称。尽管未观察到性别对杏仁核体积的影响，但 TLE 患者的同侧杏仁核体积减少可能与半球间大脑成熟率的差异有关。
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