Sirka C S, Ramam M, Mittal R, Khaitan B K, Verma K K
Department of Dermatology and Venereology, All India Institute of Medical Sciences, New Delhi - 110029, India.
Indian J Dermatol Venereol Leprol. 1999 Sep-Oct;65(5):237-9.
A 20-year-old Sikh man had palmoplantar keratoderma, flexion deformity of digits, universal alopecia, keratotic plaques at the angles of mouth, gluteal cleft, knees and dorsal aspects of the metacarpophalangeal joints of the hand; features of Olmsted syndrome. He had normal nails, teeth, oral mucosa and normal joint movements. Treatment with acitretin, 25mg/day for three and a half months, followed by 25mg once daily alternating with 50mg once daily for 3 months resulted in significant improvement.
一名20岁的锡克教男性患有掌跖角化病、手指屈曲畸形、全身脱发、口角、臀沟、膝盖和手部掌指关节背侧有角化性斑块；具有奥姆斯特德综合征的特征。他的指甲、牙齿、口腔黏膜正常，关节活动也正常。使用阿维A治疗，开始时每日25mg，持续三个半月，随后每日25mg与每日50mg交替使用3个月，病情得到显著改善。
