Department of Internal Medicine, Section of Digestive Diseases, Yale University School of Medicine, New Haven, CT 06510, USA.
J Clin Gastroenterol. 2011 Apr;45(4):314-6. doi: 10.1097/MCG.0b013e3181f5978a.
Eosinophilic myenteric ganglionitis is a disorder characterized by infiltration of the Auerbach plexus by eosinophils. It can be associated with a bowel dysmotility and a few cases of intestinal pseudo-obstructive syndrome have been described in children. In this case report, we present an elderly 93-year-old woman who presented with episodes of functional bowel obstruction of unknown etiology. After several admissions for recurrent obstipation requiring fecal disimpaction, she had a Hartmann procedure performed with a resection of the sigmoid colon. The sigmoid colon was markedly dilated and the only significant finding on histology was infiltration of the Auerbach plexus by eosinophils. The mucosa and the muscular layers appeared unremarkable. Her symptoms resolved after the resection and the patient is currently well after 5 months. Recurrent gastrointestinal pseudo-obstruction can arise secondary to eosinophilic myenteric ganglionitis even in adults. Clinical improvement is likely if this disease entity is promptly recognized and treated.
嗜酸性细胞性肌间神经丛炎是一种以嗜酸性粒细胞浸润奥厄巴赫丛为特征的疾病。它可能与肠道动力障碍有关,在儿童中已经描述了少数几例肠假性梗阻综合征的病例。在本病例报告中,我们介绍了一位 93 岁的老年女性,她因不明原因的功能性肠梗阻反复发作就诊。在多次因反复便秘需要灌肠通便而入院后,她接受了 Hartmann 手术,切除了乙状结肠。乙状结肠明显扩张,组织学上唯一的显著发现是嗜酸性粒细胞浸润奥厄巴赫丛。黏膜和肌层未见明显异常。切除后她的症状缓解,目前术后 5 个月恢复良好。即使在成人中,嗜酸性细胞性肌间神经丛炎也可继发复发性胃肠道假性梗阻。如果及时识别和治疗这种疾病,临床症状可能会改善。