Degtiarenko T V
Oftalmol Zh. 1990(7):428-32.
The paper analyses results of experimental studies conducted in 60 guinea pigs with the purpose to determine the influence of preparations of a group of distillate (torfot, FiBS) and protein preparations of vegetable (aloe extract) and animal (extract of placenta) origin on the development of a reaction of hypersensitivity of a delayed type. It was found that tissue preparations both in doses adequate to those used in clinic (0.03 ml) and in doses biologically active in pharmacologic tests (0.3 ml) don't stimulate the development of anaphylactic shock and the usage of FiBS leads to a remarkable reduction of its manifestations in experimental animals. The results obtained speak about the difference between immunomodulating influence of the preparation of a group of distillates and protein preparations on the development of anaphylaxis and allow to show, for the first time, a desensitizing action of a bioregulator of medicinal peloids (FiBS).
本文分析了在60只豚鼠身上进行的实验研究结果,目的是确定一组馏出物制剂(torfot、FiBS)以及植物源(芦荟提取物)和动物源(胎盘提取物)蛋白质制剂对迟发型超敏反应发展的影响。结果发现,无论是临床使用剂量(0.03毫升)还是药理试验中有生物活性的剂量(0.3毫升),组织制剂均不会刺激过敏性休克的发生,且使用FiBS可显著减轻实验动物中过敏性休克的表现。所得结果表明一组馏出物制剂和蛋白质制剂在免疫调节对过敏反应发展的影响方面存在差异,并首次显示了药用泥炭生物调节剂(FiBS)的脱敏作用。