[Disorders of blood platelet homeostasis in patients with multiple myeloma before the treatment and during remission].

In 28 patients with plasmocytoma selected parameters of primary haemostasis were studied before treatment and 6-9 months later, in remission. We evaluated spontaneous aggregation, aggregation induced by ADP and adrenaline, platelet factor 3 availability and the realising platelet factor 4. Significant disturbances of primary haemostasis were particularly marked in patients with a high monoclonal protein concentration (greater than 3 g/dl). During remission an increase of platelet aggregation was noted. Its values, however, remained lower than in the control group.