Department of Pathology, University of Michigan, Ann Arbor, MI 48109, USA.
Arch Pathol Lab Med. 2010 Oct;134(10):1450-4. doi: 10.5858/2010-0227-CR.1.
A resected adenocarcinoma illustrates challenges in diagnosing bronchioloalveolar carcinoma (BAC). Bronchioloalveolar carcinoma is defined by lack of invasion, something that may be difficult to assess in scars. Small (≤0.5 cm) invasive foci have little impact on the good prognosis associated with low-stage tumors. The term microinvasive adenocarcinoma or minimally invasive adenocarcinoma has been proposed for otherwise typical BACs and small invasive foci measuring 0.5 cm or less. Larger areas of invasion are associated with a more aggressive course and more reliably distinguish BAC from other variants of adenocarcinoma. Separating BAC from other forms of adenocarcinoma is important owing to differences in prognosis and emerging therapeutic strategies.
切除的腺癌说明了诊断细支气管肺泡癌 (BAC) 的挑战。细支气管肺泡癌的定义是缺乏侵袭性，这在疤痕中可能难以评估。小的（≤0.5 厘米）侵袭性病灶对与低分期肿瘤相关的良好预后影响不大。对于其他典型的 BAC 和大小为 0.5 厘米或更小的小侵袭性病灶，提出了微侵袭性腺癌或最小侵袭性腺癌的术语。更大的侵袭面积与更具侵袭性的病程相关，并更可靠地将 BAC 与腺癌的其他变体区分开来。由于预后和新兴治疗策略的差异，将 BAC 与其他形式的腺癌区分开来很重要。
