Galbraith R A, Kappas A
Rockefeller University Hospital, New York, N.Y.
Pharmacology. 1990;41(5):292-8. doi: 10.1159/000138738.
Profound obesity is conferred on the Zucker rat by homozygosity for a recessive gene (fa/fa); the heterozygous animal is lean. Subcutaneous administration of the heme analogue cobalt-protoporphyrin produces a long-sustained reduction in body weight of the homozygous Zucker rat. Intracerebroventricular injection of the compound, in a single small dose, results in an extremely prolonged (approximately 300 days) lowering of the 'set point' for body weight regulation, confirming a central nervous system action of the metalloporphyrin. The effect of cobalt-protoporphyrin is so pronounced that the phenotype of the homozygous, obese Zucker rat is changed to that of its lean littermate.
纯合隐性基因（fa/fa）使 Zucker 大鼠出现严重肥胖；杂合动物则体型瘦。皮下注射血红素类似物钴原卟啉可使纯合 Zucker 大鼠体重长期持续降低。脑室内注射一次小剂量该化合物，会导致体重调节的“设定点”极度延长降低（约 300 天），证实了金属卟啉的中枢神经系统作用。钴原卟啉的作用非常显著，以至于纯合肥胖 Zucker 大鼠的表型转变为其瘦同窝仔鼠的表型。
