Thornhill J A, Taylor B, Marshall W, Parent K
Physiol Behav. 1982 Nov;29(5):841-6. doi: 10.1016/0031-9384(82)90334-1.
Food intake over 90 min post-injection was studied in groups of food deprived (20 hr) female Sprague-Dawley (S.D.) rats, fatty Zucker (fa/fa) rats and their heterozygous lean litter mates (Fa/fa) of various ages, that bar-pressed for food pellets on a FR-1 schedule following a subcutaneous (SC) or an intracerebroventricular (IVT) injection of sterile saline or naloxone HCl. Subcutaneous injections of naloxone HCl (10 mg/kg) reduced feeding in all three groups of rats compared to SC saline; in addition, a greater percentage reduction in food intake over the whole 90 min test period occurred in the fa/fa rats given SC naloxone compared to the Fa/fa group. Intracerebroventricular naloxone (50 micrograms) decreased feeding over the initial 30 min period in the S.D. and Fa/fa rats but a 100 micrograms IVT dose was needed to reduce feeding in the fa/fa group. The results demonstrate that central naloxone administration can suppress feeding in both non-obese and obese strains of rats as it is known to do when given peripherally. These findings add yet further evidence to the premise that endogenous opioid peptides may play an intricate and important physiological role in the regulation of feeding behavior.
在禁食（20小时）的不同年龄雌性斯普拉格-道利（S.D.）大鼠、肥胖型 Zucker（fa/fa）大鼠及其杂合子瘦型同窝仔鼠（Fa/fa）中，研究了注射后90分钟内的食物摄入量。这些大鼠在皮下（SC）或脑室内（IVT）注射无菌生理盐水或盐酸纳洛酮后，按照FR-1程序按压杠杆获取食物颗粒。与皮下注射生理盐水相比，皮下注射盐酸纳洛酮（10毫克/千克）可减少所有三组大鼠的进食量；此外，与Fa/fa组相比，给予皮下纳洛酮的fa/fa大鼠在整个90分钟测试期内食物摄入量的减少百分比更大。脑室内注射纳洛酮（50微克）在最初30分钟内减少了S.D.大鼠和Fa/fa大鼠的进食量，但fa/fa组需要100微克的脑室内注射剂量才能减少进食量。结果表明，如已知外周给药时那样，中枢给予纳洛酮可抑制非肥胖和肥胖品系大鼠的进食。这些发现进一步证明了内源性阿片肽可能在进食行为调节中发挥复杂而重要的生理作用这一前提。
