Lyme Brook Centre, Stoke on Trent, UK.
J Psychopharmacol. 2010 Nov;24(4 Suppl):51-60. doi: 10.1177/1359786810385489.
People with schizophrenia are more likely to die prematurely than the general population from both suicide and physical ill health. Published studies examining the incidence of cancer in schizophrenia patients report increased, reduced or similar incidence compared with the general population. Older studies tended to report lower incidence rates which fuelled speculation as to the biological and other mechanisms for this protective effect. Furthermore, mortality rates in patients with schizophrenia appear higher than expected. We undertook a non-systematic review of published data to give an overview for these variable findings and illustrate methodological confounders by highlighting a systematic review of breast cancer studies.
精神分裂症患者的自杀和身体健康问题导致其早逝的可能性高于一般人群。已发表的研究报告显示，与普通人群相比，精神分裂症患者的癌症发病率有所增加、减少或相似。早期的研究报告发病率较低，这引发了人们对这种保护作用的生物学和其他机制的猜测。此外，精神分裂症患者的死亡率似乎高于预期。我们对已发表的数据进行了非系统性回顾，以概述这些不同发现，并通过强调乳腺癌研究的系统评价来说明方法学上的混杂因素。
