社区精神分裂症队列 25 年死亡率。
Twenty-five year mortality of a community cohort with schizophrenia.
机构信息
Hampshire Partnership NHS Trust, Southampton, UK.
出版信息
Br J Psychiatry. 2010 Feb;196(2):116-21. doi: 10.1192/bjp.bp.109.067512.
Abstract
BACKGROUND
People with schizophrenia have significantly raised mortality but we do not know how these mortality patterns in the UK have changed since the 1990s.
AIMS
To measure the 25-year mortality of people with schizophrenia with particular focus on changes over time.
METHOD
Prospective record linkage study of the mortality of a community cohort of 370 people with schizophrenia.
RESULTS
The cohort had an all-cause standardised mortality ratio of 289 (95% CI 247-337). Most deaths were from the common causes seen in the general population. Unnatural deaths were concentrated in the first 5 years of follow-up. There was an indication that cardiovascular mortality may have increased relative to the general population (P = 0.053) over the course of the study.
CONCLUSIONS
People with schizophrenia have a mortality risk that is two to three times that of the general population. Most of the extra deaths are from natural causes. The apparent increase in cardiovascular mortality relative to the general population should be of concern to anyone with an interest in mental health.
摘要
背景
精神分裂症患者的死亡率显著升高，但我们不知道自 20 世纪 90 年代以来，英国的这些死亡率模式发生了怎样的变化。
目的
测量患有精神分裂症的人群 25 年的死亡率，特别关注随时间的变化。
方法
对一个社区精神分裂症患者队列（370 人）的死亡率进行前瞻性记录链接研究。
结果
该队列的全因标准化死亡率为 289（95%CI 247-337）。大多数死亡是由普通人群中常见的原因导致的。非自然死亡主要集中在随访的前 5 年。有迹象表明，在研究过程中，心血管死亡率相对于普通人群可能有所增加（P=0.053）。
结论
精神分裂症患者的死亡率风险是普通人群的两到三倍。大多数额外的死亡是由自然原因导致的。与普通人群相比，心血管死亡率的明显增加应该引起任何关注精神健康的人的关注。
相似文献
1
Twenty-five year mortality of a community cohort with schizophrenia.社区精神分裂症队列 25 年死亡率。
Br J Psychiatry. 2010 Feb;196(2):116-21. doi: 10.1192/bjp.bp.109.067512.
2
3
Causes of the excess mortality of schizophrenia.精神分裂症超额死亡率的原因。
Br J Psychiatry. 2000 Sep;177:212-7. doi: 10.1192/bjp.177.3.212.
4
Excess mortality and shortened life expectancy in people with major mental illnesses in Taiwan.台湾主要精神疾病患者的超额死亡率和预期寿命缩短。
Epidemiol Psychiatr Sci. 2020 Aug 14;29:e156. doi: 10.1017/S2045796020000694.
5
Mortality trends in cardiovascular causes in schizophrenia, bipolar and unipolar mood disorder in Sweden 1987-2010.1987 - 2010年瑞典精神分裂症、双相情感障碍和单相情感障碍患者心血管病因死亡率趋势
Eur J Public Health. 2016 Oct;26(5):867-871. doi: 10.1093/eurpub/ckv245. Epub 2016 Jan 8.
6
Mortality gap for people with bipolar disorder and schizophrenia: UK-based cohort study 2000-2014.双相情感障碍和精神分裂症患者的死亡率差距：英国基于队列的研究 2000-2014 年。
Br J Psychiatry. 2017 Sep;211(3):175-181. doi: 10.1192/bjp.bp.117.202606. Epub 2017 Jul 6.
7
Mortality in first-contact psychosis patients in the U.K.: a cohort study.英国首发精神病患者的死亡率：一项队列研究。
Psychol Med. 2012 Aug;42(8):1649-61. doi: 10.1017/S0033291711002807. Epub 2011 Dec 13.
8
Mortality in schizophrenia and other psychoses: a 10-year follow-up of the ӔSOP first-episode cohort.精神分裂症及其他精神病的死亡率：对ӔSOP首发队列的10年随访
Schizophr Bull. 2015 May;41(3):664-73. doi: 10.1093/schbul/sbu138. Epub 2014 Sep 27.
9
Ethnicity and excess mortality in severe mental illness: a cohort study.严重精神疾病中的种族与超额死亡率：一项队列研究。
Lancet Psychiatry. 2017 May;4(5):389-399. doi: 10.1016/S2215-0366(17)30097-4. Epub 2017 Mar 16.
10
Cardiovascular drug use and mortality in patients with schizophrenia or bipolar disorder: a Danish population-based study.精神分裂症或双相情感障碍患者的心血管药物使用与死亡率：一项基于丹麦人群的研究。
Psychol Med. 2014 Jun;44(8):1625-37. doi: 10.1017/S003329171300216X. Epub 2013 Nov 18.
引用本文的文献
1
Study on disproportionality in the detection of potential signals between quetiapine and diabetic ketoacidosis.喹硫平与糖尿病酮症酸中毒之间潜在信号检测的不均衡性研究。
Eur J Clin Pharmacol. 2025 Oct;81(10):1473-1479. doi: 10.1007/s00228-025-03895-7. Epub 2025 Jul 28.
2
Development and preliminary evaluation in community mental health teams of a cervical screening informed-choice tool for women with severe mental illness in England: a mixed-method study.英格兰针对患有严重精神疾病女性的宫颈癌筛查知情选择工具在社区精神卫生团队中的开发与初步评估：一项混合方法研究
BMJ Open. 2025 Jul 8;15(7):e105777. doi: 10.1136/bmjopen-2025-105777.
3
Rates of metabolic syndrome in Queensland adult community mental health consumers with schizophrenia and related disorders: A brief report.昆士兰患有精神分裂症及相关障碍的成年社区心理健康服务消费者的代谢综合征患病率：简要报告
Australas Psychiatry. 2025 Aug;33(4):731-735. doi: 10.1177/10398562251358760. Epub 2025 Jul 4.
4
The Views of Adult Weight Management Dietitians on Service Provision for People With Obesity and Severe Mental Illness and/or Learning Disability: A Qualitative Study.成人体重管理营养师对肥胖及严重精神疾病和/或学习障碍患者服务提供的看法：一项定性研究
Nutr Bull. 2025 Sep;50(3):459-471. doi: 10.1111/nbu.70013. Epub 2025 Jun 5.
5
Ningbo Schizophrenia Cohort (NSC)-a longitudinal ambispective cohort based on electronic health records: cohort profile.宁波精神分裂症队列（NSC）——基于电子健康记录的纵向双向队列：队列简介
BMJ Open. 2025 May 15;15(5):e091188. doi: 10.1136/bmjopen-2024-091188.
6
DIAMONDS-a diabetes self-management intervention for people with severe mental illness: protocol for an individually randomised controlled multicentre trial.DIAMONDS——一项针对重症精神疾病患者的糖尿病自我管理干预措施：一项个体随机对照多中心试验方案
BMJ Open. 2025 Mar 27;15(3):e090295. doi: 10.1136/bmjopen-2024-090295.
7
Physiotherapy Within Inpatient Mental Health Wards: Involvement, Diagnoses, and Lifestyle Characteristics.住院精神科病房中的物理治疗：参与情况、诊断及生活方式特征
Healthcare (Basel). 2025 Jan 30;13(3):279. doi: 10.3390/healthcare13030279.
8
Impact of age of onset on the course of chronic schizophrenia: factors associated with first hospitalization in a large-scale cross-sectional study.起病年龄对慢性精神分裂症病程的影响：一项大规模横断面研究中与首次住院相关的因素
Eur Arch Psychiatry Clin Neurosci. 2025 Jan 21. doi: 10.1007/s00406-025-01959-4.
9
Increased mortality risk in people with schizophrenia in Lithuania 2001-2020.2001 - 2020年立陶宛精神分裂症患者的死亡风险增加。
Schizophrenia (Heidelb). 2025 Jan 16;11(1):7. doi: 10.1038/s41537-024-00549-y.
10
Negative Association Between Schizophrenia and Subsequent Cancer Diagnoses-A Retrospective Cohort Study from Germany.精神分裂症与后续癌症诊断之间的负相关——一项来自德国的回顾性队列研究。
Eur J Investig Health Psychol Educ. 2024 Nov 26;14(12):2957-2965. doi: 10.3390/ejihpe14120194.
本文引用的文献
1
A systematic review of mortality in schizophrenia: is the differential mortality gap worsening over time?精神分裂症死亡率的系统评价：不同死亡率差距是否随时间推移而恶化？
Arch Gen Psychiatry. 2007 Oct;64(10):1123-31. doi: 10.1001/archpsyc.64.10.1123.
2
Mortality among patients with schizophrenia and reduced psychiatric hospital care.精神分裂症患者及精神科住院护理减少情况下的死亡率。
Psychol Med. 2005 May;35(5):725-32. doi: 10.1017/s0033291704004118.
3
Adverse metabolic effects associated with atypical antipsychotics: literature review and clinical implications.非典型抗精神病药物相关的不良代谢效应：文献综述与临床意义
Drugs. 2004;64(7):701-23. doi: 10.2165/00003495-200464070-00003.
4
Diet, smoking and cardiovascular risk in people with schizophrenia: descriptive study.精神分裂症患者的饮食、吸烟与心血管风险：描述性研究。
Br J Psychiatry. 2003 Dec;183:534-9. doi: 10.1192/bjp.183.6.534.
5
The excess mortality of the insane.精神病患者的超额死亡率。
Acta Psychiatr Neurol Scand. 1952;27(3-4):353-67.
6
Mortality in chronic schizophrenia during decreasing number of psychiatric beds in Finland.芬兰精神科床位数量减少期间慢性精神分裂症患者的死亡率
Schizophr Res. 2002 Apr 1;54(3):265-75. doi: 10.1016/s0920-9964(01)00281-x.
7
Cause-specific mortality in psychiatric patients after deinstitutionalisation.非机构化治疗后精神科患者的特定病因死亡率。
Br J Psychiatry. 2001 Nov;179:438-43. doi: 10.1192/bjp.179.5.438.
8
Causes of the excess mortality of schizophrenia.精神分裂症超额死亡率的原因。
Br J Psychiatry. 2000 Sep;177:212-7. doi: 10.1192/bjp.177.3.212.
9
Mortality in Western Australian psychiatric patients.西澳大利亚州精神病患者的死亡率。
Soc Psychiatry Psychiatr Epidemiol. 2000 Aug;35(8):341-7. doi: 10.1007/s001270050248.
10
Time trends in schizophrenia mortality in Stockholm county, Sweden: cohort study.瑞典斯德哥尔摩郡精神分裂症死亡率的时间趋势：队列研究。
BMJ. 2000;321(7259):483-4. doi: 10.1136/bmj.321.7259.483.
Zotero 插件