Hampshire Partnership NHS Trust, Southampton, UK.
Br J Psychiatry. 2010 Feb;196(2):116-21. doi: 10.1192/bjp.bp.109.067512.
People with schizophrenia have significantly raised mortality but we do not know how these mortality patterns in the UK have changed since the 1990s.
To measure the 25-year mortality of people with schizophrenia with particular focus on changes over time.
Prospective record linkage study of the mortality of a community cohort of 370 people with schizophrenia.
The cohort had an all-cause standardised mortality ratio of 289 (95% CI 247-337). Most deaths were from the common causes seen in the general population. Unnatural deaths were concentrated in the first 5 years of follow-up. There was an indication that cardiovascular mortality may have increased relative to the general population (P = 0.053) over the course of the study.
People with schizophrenia have a mortality risk that is two to three times that of the general population. Most of the extra deaths are from natural causes. The apparent increase in cardiovascular mortality relative to the general population should be of concern to anyone with an interest in mental health.
精神分裂症患者的死亡率显著升高，但我们不知道自 20 世纪 90 年代以来，英国的这些死亡率模式发生了怎样的变化。
测量患有精神分裂症的人群 25 年的死亡率，特别关注随时间的变化。
对一个社区精神分裂症患者队列（370 人）的死亡率进行前瞻性记录链接研究。
该队列的全因标准化死亡率为 289（95%CI 247-337）。大多数死亡是由普通人群中常见的原因导致的。非自然死亡主要集中在随访的前 5 年。有迹象表明，在研究过程中，心血管死亡率相对于普通人群可能有所增加（P=0.053）。
精神分裂症患者的死亡率风险是普通人群的两到三倍。大多数额外的死亡是由自然原因导致的。与普通人群相比，心血管死亡率的明显增加应该引起任何关注精神健康的人的关注。
