在酿酒酵母的有丝分裂前期，依赖于 Cdc14 的动粒蛋白去磷酸化。
Cdc14-dependent dephosphorylation of a kinetochore protein prior to anaphase in Saccharomyces cerevisiae.
机构信息
Fred Hutchinson Cancer Research Center, Molecular and Cellular Biology Program, University of Washington, Seattle, Washington 98195, USA.
出版信息
Genetics. 2010 Dec;186(4):1487-91. doi: 10.1534/genetics.110.123653. Epub 2010 Oct 5.
Abstract
The budding yeast Cdc14 phosphatase reverses Cdk1 phosphorylation to promote mitotic exit. Although Cdc14 activity is thought to be restricted to anaphase, we found that dephosphorylation of the Dsn1 kinetochore protein in metaphase requires Cdc14. These data suggest that there is a nonnucleolar pool of active Cdc14 prior to anaphase.
摘要
芽殖酵母 Cdc14 磷酸酶可逆转 Cdk1 的磷酸化，从而促进有丝分裂退出。虽然认为 Cdc14 的活性受到限制，只能在后期发挥作用，但我们发现，中期 Dsn1 着丝粒蛋白的去磷酸化需要 Cdc14。这些数据表明，在后期之前，存在一个非核仁的活跃 Cdc14 池。
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