Augenklinik (TKW), HELIOS Kliniken Schwerin, Germany.
J Neuroophthalmol. 2011 Mar;31(1):34-7. doi: 10.1097/WNO.0b013e3181f33bc2.
In this case series and review of the literature, we describe 2 cases of abducens neuromyotonia (ANM) as the presenting sign of an intracranial tumor (meningioma). Review of the literature suggests that the pathophysiology of ocular neuromyotonia is incompletely understood. Most patients with ANM have a history of radiation therapy. The diagnosis of ANM is made on the basis of clinical findings and can be supported by electrophysiological studies. A complete neurologic examination is mandatory for patients with ANM. Treatment consists of eliminating the underlying cause; carbamazepine is effective in alleviating the symptoms of ANM. Neuroimaging should be performed if patients with ANM lack the typical history of radiation therapy, as ANM may be the presenting sign of an intracranial mass.
在本病例系列和文献回顾中，我们描述了 2 例以展神经肌强直性放电（ANM）为首发表现的颅内肿瘤（脑膜瘤）。文献回顾表明，眼肌强直性放电的病理生理学尚未完全清楚。大多数 ANM 患者有放射治疗史。ANM 的诊断基于临床发现，可以通过电生理研究来支持。对于 ANM 患者，必须进行全面的神经系统检查。治疗包括消除潜在病因；卡马西平可有效缓解 ANM 的症状。如果 ANM 患者缺乏典型的放射治疗史，应进行神经影像学检查，因为 ANM 可能是颅内肿块的首发表现。
