Shahid Beheshti University of Medical Sciences, Tehran, Iran.
J Addict Dis. 2010 Oct;29(4):449-54. doi: 10.1080/10550887.2010.509278.
The aim of study was determine the effect of ultra-rapid opiate detoxification (UROD) on the presence or absence of withdrawal syndrome in a group of patients with opiate dependency. In this study, withdrawal syndrome of 173 patients with opiate addiction was evaluated before and after UROD using the Objective Opioid Withdrawal Scale. Hence, each patient was observed for 5 minutes before UROD and at different hours afterward to observe any withdrawal sign. The most prevalent withdrawal sign before UROD was anxiety. Restlessness was the most prevalent finding at 1, 3, and 6 hours. After 12 hours, yawning was reported as the most prevalent finding in 39 participants. Anxiety was reported as the most prevalent finding in 61 participants after 24 hours. Patients with opioid dependency who underwent UROD showed the highest rate of withdrawal symptoms at one hour after anesthesia. Most of these symptoms subsided after 24 hours. UROD can be applied for detoxification of patients with opioid dependency with safety.
本研究旨在探讨超快速阿片类药物戒毒（UROD）对阿片类药物依赖患者戒断综合征出现与否的影响。在这项研究中，使用客观阿片戒断量表（Objective Opioid Withdrawal Scale）评估了 173 名阿片类药物成瘾患者在 UROD 前后的戒断综合征。因此，在 UROD 前和之后的不同时间点，对每位患者观察 5 分钟，以观察任何戒断迹象。UROD 前最常见的戒断症状是焦虑。1、3 和 6 小时时最常见的发现是烦躁不安。12 小时后，39 名参与者报告说打哈欠是最常见的发现。24 小时后，61 名参与者报告说焦虑是最常见的发现。接受 UROD 的阿片类药物依赖患者在麻醉后 1 小时表现出最高的戒断症状发生率。这些症状大多在 24 小时后缓解。UROD 可用于安全戒毒阿片类药物依赖患者。
