Mirhosseini Hamid, Kargar Masoud, Nitsche Michael, Sheikhi Abarghouei Mohammad Ali, Nazari Mohammad Ali, Dastjerdi Ghasem
Department of Psychiatry, Research Center of Addiction and Behavioral Sciences, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Department of Anesthesia, Faculty of Allied Medical Sciences, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Basic Clin Neurosci. 2022 Nov-Dec;13(6):799-806. doi: 10.32598/bcn.2021.1573.1. Epub 2022 Nov 1.
The persistence of post-detoxification problems in drug addiction is one of the disadvantages of the ultra-rapid opioid detoxification (UROD) method. Transcranial direct current stimulation (tDCS) has been introduced in experimental addiction treatment for some years. Results of pilot studies suggest that it might be a promising method for addiction treatment. This study explores the adjunctive application of tDCS during treating opiate addiction with the UROD approach.
This double-blind, sham-controlled clinical trial was carried out on patients with substance abuse admitted to the Bahman Clinic of Yazd City in Iran (from March to September 2014). Forty participants were randomly allocated to treatment and control groups. Two sessions of tDCS (real or sham) over dorsolateral prefrontal cortices (DLPFC) were applied, accompanied by UROD. Withdrawal symptoms and craving were assessed by the drug desire questionnaire and objective opiate withdrawal scale before UROD and for the 24-hour interval after.
Transcranial direct current stimulation optimized the opiate addiction treatment through craving and withdrawal syndrome alleviation.
The study results indicate that prefrontal tDCS may promote the efficacy of the UROD method in opioid addiction.
药物成瘾后脱毒问题的持续存在是超快速阿片类药物脱毒（UROD）方法的缺点之一。经颅直流电刺激（tDCS）已在实验性成瘾治疗中应用数年。初步研究结果表明，它可能是一种有前途的成瘾治疗方法。本研究探讨tDCS在采用UROD方法治疗阿片类成瘾过程中的辅助应用。
本双盲、假对照临床试验于伊朗亚兹德市巴赫曼诊所收治的药物滥用患者中开展（2014年3月至9月）。40名参与者被随机分配至治疗组和对照组。在背外侧前额叶皮质（DLPFC）进行了两疗程的tDCS（真实或假刺激），同时采用UROD。在UROD前及之后的24小时间隔内，通过药物渴望问卷和客观阿片类药物戒断量表评估戒断症状和渴望程度。
经颅直流电刺激通过减轻渴望和戒断综合征优化了阿片类成瘾治疗。
研究结果表明，前额叶tDCS可能提高UROD方法治疗阿片类成瘾的疗效。
