Oguro N, Momoi M, Nakamigawa T, Miyamoto S, Kobayashi S, Miyao M, Kamoshita S
Department of Pediatrics, Jichi Medical School, Tochigi, Japan.
Brain Dev. 1990;12(6):753-9. doi: 10.1016/s0387-7604(12)80001-5.
The results of the first multi-institutional survey of the Rett syndrome in Japan are reported. The survey was performed during 1985 and 1986. Eighty-nine cases were collected, of which 54 cases were confirmed to have the Rett syndrome. The ages of the patients ranged between 1 and 26 years. The clinical onsets occurred after 18 months of age in 28 cases, and before the age of one year in 26. No familial cases nor consanguinity was found. The incidence of perinatal abnormalities among the patients was not significantly higher than in other diseases in which no perinatal factors are involved.
报告了日本首次关于雷特综合征的多机构调查结果。该调查在1985年至1986年期间进行。共收集到89例病例，其中54例被确诊为雷特综合征。患者年龄在1岁至26岁之间。28例患者的临床发病发生在18个月龄之后，26例发生在1岁之前。未发现家族性病例或近亲结婚情况。患者围产期异常的发生率并不显著高于其他不涉及围产期因素的疾病。
