Huskisson E C
King Edward VII Hospital, London, UK.
J Int Med Res. 2010 Jul-Aug;38(4):1175-212. doi: 10.1177/147323001003800401.
Osteoarthritis (OA) is the most common form of arthritis and it is often associated with significant disability and impaired quality of life. Once thought to be caused by an age-related 'wearing out' of articular cartilage, it is now recognized to be a dynamic process in which cartilage degradation alternates with repair. Several expert guidelines for the management of OA exist, which concur in their recommendations for a stepwise approach to the employment of pharmacological agents and the introduction of suggestions to extend the use of agents such as topical non-steroidal anti-inflammatory drugs, especially for mild-to-moderate forms of the disease. They also emphasize the importance of non-pharmacological measures, such as nutraceuticals, education, diet, exercise and the use of aids in improving signs and symptoms and slowing progression. In many countries, effective medicinal and nutraceutical agents are available 'over-the-counter'. This review explains the modern approach to the management of mild-to-moderate osteoarthritic pain.
骨关节炎（OA）是最常见的关节炎形式，常伴有严重残疾和生活质量受损。曾被认为是由与年龄相关的关节软骨“磨损”所致，现在人们认识到它是一个动态过程，其中软骨降解与修复交替进行。目前存在多个骨关节炎管理的专家指南，这些指南在采用逐步使用药物制剂的方法以及引入扩大使用局部非甾体抗炎药等制剂的建议方面达成了一致，特别是对于轻至中度形式的疾病。它们还强调了非药物措施的重要性，如营养保健品、教育、饮食、运动以及使用辅助器具来改善体征和症状并减缓病情进展。在许多国家，有效的药物和营养保健品可在“非处方药”渠道获得。本综述解释了轻至中度骨关节炎疼痛管理的现代方法。
