Zhumadilov Zh Sh, Makarenkova R V
Antibiot Khimioter. 1990 Nov;35(11):37-8.
Pharmacokinetics of kanamycin was studied after its targeted delivery to the liver in autological erythrocyte ghosts on 25 noninbred dogs with experimental acute cholecystitis in comparison to the routine intravenous administration of the antibiotic in solution. Kanamycin concentrations in the tissues of the liver, pancreas, spleen, kidneys and lungs as well as in bile and blood serum were determined by the agar diffusion method 24, 48 and 72 hours after the last administration. It was found that the targeted delivery of kanamycin in blood shadows made it possible to provide high concentrations of the antibiotic for prolonged periods in the liver and biliary ducts and to more efficiently arrest the clinical manifestations of acute cholecystitis as well as normalize the laboratory indices. The data showed that using blood shadows as a reliable system for targeted delivery of antibiotics to the liver was advisable in purulent inflammatory affections of the biliary ducts.
在25只患有实验性急性胆囊炎的非近亲犬中，研究了卡那霉素在自体红细胞影介导下靶向递送至肝脏后的药代动力学，并与常规静脉注射抗生素溶液进行了比较。在最后一次给药后24、48和72小时，通过琼脂扩散法测定肝脏、胰腺、脾脏、肾脏和肺组织以及胆汁和血清中的卡那霉素浓度。结果发现，卡那霉素通过血影靶向递送能够在肝脏和胆管中长期维持高浓度的抗生素，更有效地抑制急性胆囊炎的临床表现，并使实验室指标恢复正常。数据表明，在胆管化脓性炎症中，将血影作为抗生素靶向递送至肝脏的可靠系统是可取的。
