Bettinardi V, Picchio M, Di Muzio N, Gianolli L, Messa C, Gilardi M C
Department of Nuclear Medicine, San Raffaele Scientific Institute, Milan, Italy.
Q J Nucl Med Mol Imaging. 2010 Oct;54(5):455-75.
This paper focuses on acquisition and processing methods in positron emission tomography/computed tomography (PET/CT) for radiotherapy (RT) applications. The recent technological evolutions of PET/CT systems are described. Particular emphasis is dedicated to the tools needed for the patient positioning and immobilization, to be used in PET/CT studies as well as during RT treatment sessions. The effect of organ and lesion motion due to patient's respiration on PET/CT imaging is discussed. Breathing protocols proposed to minimize PET/CT spatial mismatches in relation to respiratory movements are illustrated. The respiratory gated (RG) 4D-PET/CT techniques, developed to measure and compensate for organ and lesion motion, are then introduced. Finally a description is provided of different acquisition and data processing techniques, implemented with the aim at improving: i) image quality and quantitative accuracy of PET images, and ii) target volume definition and treatment planning in RT, by using specific and personalised motion information.
本文重点关注正电子发射断层扫描/计算机断层扫描（PET/CT）在放射治疗（RT）应用中的采集和处理方法。描述了PET/CT系统的最新技术进展。特别强调了患者定位和固定所需的工具，这些工具将用于PET/CT研究以及RT治疗过程中。讨论了患者呼吸引起的器官和病变运动对PET/CT成像的影响。阐述了为尽量减少与呼吸运动相关的PET/CT空间不匹配而提出的呼吸协议。接着介绍了为测量和补偿器官及病变运动而开发的呼吸门控（RG）4D-PET/CT技术。最后描述了不同的采集和数据处理技术，其实施目的在于通过使用特定的个性化运动信息来提高：i）PET图像的图像质量和定量准确性，以及ii）RT中的靶区体积定义和治疗计划。
