Nuclear Medicine, San Raffaele Scientific Institute, Milan, Italy.
Radiother Oncol. 2010 Sep;96(3):311-6. doi: 10.1016/j.radonc.2010.07.014. Epub 2010 Aug 12.
To describe the degradation effects produced by respiratory organ and lesion motion on PET/CT images and to define the role of respiratory gated (RG) 4D-PET/CT techniques to compensate for such effects.
Based on the literature and on our own experience, technical recommendations and clinical indications for the use of RG 4D PET/CT have been outlined.
RG 4D-PET/CT techniques require a state of the art PET/CT scanner, a respiratory monitoring system and dedicated acquisition and processing protocols. Patient training is particularly important to obtain a regular breathing pattern. An adequate number of phases has to be selected to balance motion compensation and statistical noise. RG 4D PET/CT motion free images may be clinically useful for tumour tissue characterization, monitoring patient treatment and target definition in radiation therapy planning.
RG 4D PET/CT is a valuable tool to improve image quality and quantitative accuracy and to assess and measure organ and lesion motion for radiotherapy planning.
描述呼吸器官和病变运动对 PET/CT 图像产生的衰减效应，并定义呼吸门控（RG）4D-PET/CT 技术在补偿这些效应中的作用。
基于文献和我们自己的经验，概述了 RG 4D PET/CT 的技术建议和临床应用指征。
RG 4D-PET/CT 技术需要一台先进的 PET/CT 扫描仪、一个呼吸监测系统和专门的采集和处理协议。患者培训对于获得规律的呼吸模式非常重要。必须选择足够多的相位来平衡运动补偿和统计噪声。RG 4D PET/CT 无运动图像可能对肿瘤组织特征化、监测患者治疗和放射治疗计划中的靶区定义具有临床价值。
RG 4D PET/CT 是一种提高图像质量和定量准确性的有价值的工具，可用于评估和测量放射治疗计划中的器官和病变运动。
