Am J Gastroenterol. 2010 Oct;105(10):2150-2. doi: 10.1038/ajg.2010.257.
Patients with achalasia have an increased risk for the development of esophageal squamous cell cancer. Endoscopic surveillance in long-standing achalasia has been advocated by some, but the most recent American Society of Gastrointesinal Endoscopy guidelines regard current data as insufficient to support such an approach. In this issue of the American Journal of Gastroenterology, Leeuwenburgh and colleagues report on the results of a long-term prospective study with fixed surveillance intervals. The authors confirm earlier observations of an increased cancer risk after 10 years of symptomatic achalasia. Despite some limitations, this study and earlier data suggest that it might be worthwhile to consider endoscopic surveillance in patients with long-standing achalasia.
贲门失弛缓症患者发生食管鳞状细胞癌的风险增加。一些人主张对长期贲门失弛缓症患者进行内镜监测,但最近美国胃肠内镜学会指南认为目前的数据不足以支持这种方法。在本期《美国胃肠病学杂志》中,Leeuwenburgh 及其同事报告了一项具有固定监测间隔的长期前瞻性研究结果。作者证实了早期观察到的症状性贲门失弛缓症 10 年后癌症风险增加的结果。尽管存在一些局限性,但这项研究和早期数据表明,对长期贲门失弛缓症患者进行内镜监测可能是值得的。