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生长期和休止期毛发外根鞘的免疫荧光：对天疱疮诊断的辅助作用

Immunofluoresence of the outer root sheath in anagen and telogen hair: an aid to diagnosis in pemphigus.

作者信息

Kumaresan M, Rai Reena, Sandhya V

机构信息

Department of Dermatology, PSG Hospitals, Coimbatore, India.

出版信息

Int J Trichology. 2009 Jul;1(2):138-9. doi: 10.4103/0974-7753.58558.

DOI:10.4103/0974-7753.58558
PMID:20927237
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2938577/
Abstract

Desmoglein 1 and 3 are distributed in the outer root sheath (ORS) of the hair follicle. Direct immunofluoresence (DIF) pattern of ORS in cases of pemphigus resembles the DIF pattern of the perilesional skin. We performed a DIF of the anagen and telogen hair ORS in a case of pemphigus and correlated it with the DIF findings of perilesional skin. Telogen hair ORS promises to be a useful tool in performing DIF for the purpose of diagnosis and follow-up in cases of pemphigus.

摘要

桥粒芯蛋白1和3分布于毛囊的外根鞘。天疱疮患者毛囊外根鞘的直接免疫荧光（DIF）模式类似于皮损周围皮肤的DIF模式。我们对1例天疱疮患者生长期和休止期毛发的外根鞘进行了DIF检测，并将其与皮损周围皮肤的DIF结果进行关联。休止期毛发外根鞘有望成为天疱疮诊断和随访中进行DIF检测的有用工具。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d1f5/2938577/43e2e431ae0f/IJT-1-138-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d1f5/2938577/1c09ef87bee0/IJT-1-138-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d1f5/2938577/6e44f2abcbb5/IJT-1-138-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d1f5/2938577/43e2e431ae0f/IJT-1-138-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d1f5/2938577/1c09ef87bee0/IJT-1-138-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d1f5/2938577/6e44f2abcbb5/IJT-1-138-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d1f5/2938577/43e2e431ae0f/IJT-1-138-g003.jpg

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引用本文的文献

1
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Indian Dermatol Online J. 2017 Sep-Oct;8(5):319-322. doi: 10.4103/idoj.IDOJ_280_16.

本文引用的文献

1
Demonstration of pemphigus-specific immunofluorescence pattern by direct immunofluorescence of plucked hair.直接免疫荧光法检测拔取毛发中天疱疮特异性免疫荧光模式。
Int J Dermatol. 2009 Nov;48(11):1187-9. doi: 10.1111/j.1365-4632.2009.04153.x.
2
A study on plucked hair as a substrate for direct immunofluorescence in pemphigus vulgaris.一项关于拔毛作为寻常型天疱疮直接免疫荧光检测底物的研究。
J Eur Acad Dermatol Venereol. 2009 Feb;23(2):129-31. doi: 10.1111/j.1468-3083.2008.02948.x. Epub 2008 Aug 20.
3
Follicular acantholysis: a subtle clue to the early diagnosis of pemphigus vulgaris.
Am J Dermatopathol. 2005 Jun;27(3):237-9. doi: 10.1097/01.dad.0000138656.86095.f4.
4
Desmoglein isotype expression in the hair follicle and its cysts correlates with type of keratinization and degree of differentiation.桥粒芯糖蛋白在毛囊及其囊肿中的同种型表达与角化类型和分化程度相关。
J Invest Dermatol. 2003 Jun;120(6):1052-7. doi: 10.1046/j.1523-1747.2003.12234.x.
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Direct immunofluorescence of plucked hair in pemphigus.
Arch Dermatol. 2003 Feb;139(2):228-9. doi: 10.1001/archderm.139.2.228.
6
Desmoglein 3 anchors telogen hair in the follicle.桥粒芯糖蛋白3将休止期毛发固定在毛囊中。
J Cell Sci. 1998 Sep;111 ( Pt 17):2529-37. doi: 10.1242/jcs.111.17.2529.
7
Pemphigus and the terminal hair follicle.
J Cutan Pathol. 1991 Dec;18(6):428-31. doi: 10.1111/j.1600-0560.1991.tb01379.x.