Villalpando Karina Teixeira, Casarin Renato Correa Viana, Pimentel Suzana Peres, Cirano Fabiano Ribeiro, Casati Marcio Zafallon
Catholic University of Campinas, Sao Paulo, Brazil.
Quintessence Int. 2010 Nov-Dec;41(10):855-61.
The aim of this double-blind study was to evaluate the clinical efficacy of the association of triclosan-containing mouthrinse and dentifrice on biofilm and gingivitis reduction.
Forty patients with a diagnosis of gingivitis were selected and randomly divided into four groups (n = 10): group TT-triclosan-containing mouthrinse and triclosan-containing dentifrice; group CT-control mouthrinse and triclosan-containing dentifrice; group TC-triclosan-containing mouthrinse and control dentifrice; group CC-control mouthrinse and control dentifrice. Patients were evaluated by a calibrated examiner using a quantitative Plaque Index and Gingivitis Index at 0, 15, and 30 days. Intragroup analysis was performed by Friedman test and intergroup analysis by Kruskal-Wallis.
Intragroup evaluation revealed a statistically significant reduction in Plaque Index for groups that used triclosan, independently of the group (TT, CT, and TC) (P < .05). Intergroup analysis suggested that only the group that used the association of triclosan dentifrice and mouthrinse (group TT) demonstrated statistically reduced Plaque Index at 30 days, when compared to the control group (CC) (P < .05). With regard to gingivitis reduction, no difference was observed between groups, although the association presented a faster reduction in bleeding levels.
Only the association of triclosan dentifrice and triclosan mouthrinse statistically reduced Plaque Index, when compared to the control group; however, regarding the additional benefits to gingivitis control, more studies should be done to confirm the results.
本双盲研究旨在评估含三氯生漱口水与牙膏联合使用对减少生物膜和牙龈炎的临床疗效。
选取40例诊断为牙龈炎的患者，随机分为四组（n = 10）：TT组 - 含三氯生漱口水和含三氯生牙膏；CT组 - 对照漱口水和含三氯生牙膏；TC组 - 含三氯生漱口水和对照牙膏；CC组 - 对照漱口水和对照牙膏。由经过校准的检查者在第0、15和30天使用定量菌斑指数和牙龈炎指数对患者进行评估。组内分析采用Friedman检验，组间分析采用Kruskal - Wallis检验。
组内评估显示，使用三氯生的组（TT、CT和TC）菌斑指数均有统计学意义的降低，与组别无关（P < 0.05）。组间分析表明，与对照组（CC）相比，仅使用三氯生牙膏和漱口水联合的组（TT组）在第30天菌斑指数有统计学意义的降低（P < 0.05）。关于牙龈炎的减轻，尽管联合使用组出血水平下降更快，但各组之间未观察到差异。
与对照组相比，仅三氯生牙膏和三氯生漱口水联合使用在统计学上降低了菌斑指数；然而，关于对控制牙龈炎的额外益处，需要更多研究来证实结果。
