Watanabe J, Higuchi J, Hayashi Y, Yuasa H, Ozeki S
Department of Biopharmaceutics, Faculty of Pharmaceutical Sciences, Nagoya City University, Japan.
Chem Pharm Bull (Tokyo). 1990 Dec;38(12):3428-33. doi: 10.1248/cpb.38.3428.
Effects of oral administration of NaCl on salivary and systemic clearance of Li+ were investigated following bolus intravenous administration of LiCl in male beagle dogs. Fifty ml of NaCl solution (100 meq/l) was administered orally 7 times at 1 h intervals. Gustatory stimulation of salivation was continued for 390 min using citric acid solution. Saliva was collected by means of permanent fistulae for parotid and mandibular-sublingual glands. Salivary clearance of Li+ was markedly increased by continuous stimulation of salivation, and was enhanced further after oral administration of NaCl solution. Renal clearance of Li+ showed a decreasing tendency under continuous salivation compared with the condition without gustatory stimulation; however, this decreasing tendency disappeared after oral administration of NaCl solution. Consequently, systemic clearance of Li+ was increased due to the contribution of increased salivary clearance. Enhancement of salivary Li+ clearance after administration of NaCl suggests the salivary excretion mechanism of Li+ may include a reabsorption process, like its renal excretion. Administration of NaCl solution had similar effects on salivary and systemic clearances of K+ to those on Li+ clearances, and a significant correlation was observed between Li+ and K+ clearances of both salivary gland and kidney.
在雄性比格犬静脉注射氯化锂后，研究了口服氯化钠对唾液和全身锂（Li⁺）清除率的影响。每隔1小时口服7次50毫升氯化钠溶液（100毫当量/升）。使用柠檬酸溶液持续390分钟刺激唾液分泌。通过腮腺和下颌下腺-舌下腺的永久性瘘管收集唾液。持续刺激唾液分泌可显著提高唾液对Li⁺的清除率，口服氯化钠溶液后进一步增强。与无味觉刺激的情况相比，持续唾液分泌时肾脏对Li⁺的清除率呈下降趋势；然而，口服氯化钠溶液后这种下降趋势消失。因此，由于唾液清除率增加，全身Li⁺清除率升高。口服氯化钠后唾液Li⁺清除率的提高表明，Li⁺的唾液排泄机制可能包括一个重吸收过程，类似于其肾脏排泄。氯化钠溶液对唾液和全身钾（K⁺）清除率的影响与对Li⁺清除率的影响相似，并且在唾液腺和肾脏的Li⁺与K⁺清除率之间观察到显著相关性。
