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Synthetic cephalosporins. VII. Synthesis and antibacterial activity of 7-[(Z)-2-(2-aminothiazol-4-yl)-2-(3-(3-hydroxy-4-pyridon-1-yl)-3- carboxypropoxyimino)acetamido]-3-(1,2,3-thiadiazol-5-yl)-thiomethyl-3- cephem-4-carboxylic acid and its related compounds.

作者信息

Sakagami K, Iwamatsu K, Atsumi K, Hatanaka M

机构信息

Pharmaceutical Research Center, Meiji Seika Kaisha, Ltd., Yokohama, Japan.

出版信息

Chem Pharm Bull (Tokyo). 1990 Dec;38(12):3476-9. doi: 10.1248/cpb.38.3476.

DOI:10.1248/cpb.38.3476
PMID:2092946
Abstract

Synthesis and antibacterial activity of 7-[(Z)-2-(2-aminothiazol-4-yl)-2-(3-(3-hydroxy-4-pyridon-1-y l)-3- carboxypropoxyimino)acetamido]-3-(1,2,3-thiadiazol-5-yl)thio methyl-3-cephem-4-carboxylic acid (12a) and its related compounds are described. Compound 12a exhibited excellent antibacterial activity against gram-negative bacteria, including Pseudomonas aeruginosa.

摘要

相似文献

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Molecules. 2012 Jan 19;17(1):1025-38. doi: 10.3390/molecules17011025.