合成头孢菌素。VI. 7-[(Z)-2-(2-氨基噻唑-4-基)-2-(1-羧基-1-甲基)乙氧基亚氨基乙酰氨基]-3-(3-羟基-4-吡啶酮-1-基)甲基-3-头孢烯-4-羧酸及相关化合物的合成与抗菌活性
Synthetic cephalosporins. VI. Synthesis and antibacterial activity of 7-[(Z)-2-(2-aminothiazol-4-yl)-2-(1-carboxy-1-methyl) ethoxyiminoacetamido]- 3-(3-hydroxy-4-pyridon-1-yl)methyl-3-cephem-4-carboxylic acid and related compounds.
作者信息
Sakagami K, Iwamatsu K, Atsumi K, Hatanaka M
机构信息
Pharmaceutical Research Center, Meiji Seika Kaisha, Ltd., Yokohama, Japan.
出版信息
Chem Pharm Bull (Tokyo). 1990 Aug;38(8):2271-3. doi: 10.1248/cpb.38.2271.
PMID:2126226
Abstract
Synthesis and antibacterial activity of 7-[(Z)-2-(2-aminothiazol-4-yl)-2-(1-carboxy-1-methyl)ethoxyimin oacetamido]- 3-(3-hydroxy-4-pyridon-1-yl)-3-cephem-4-carboxylic acid (12) and its related compounds are described. Compound 12 exhibited excellent antibacterial activity against gram-negative bacteria, and its anti-pseudomonal activity was ten to fifteen times greater than that of ceftazidime.
摘要
7-[(Z)-2-(2-氨基噻唑-4-基)-2-(1-羧基-1-甲基)乙氧基亚氨基乙酰氨基]-3-(3-羟基-4-吡啶酮-1-基)-3-头孢烯-4-羧酸(12)及其相关化合物的合成与抗菌活性已被描述。化合物12对革兰氏阴性菌表现出优异的抗菌活性，其抗假单胞菌活性比头孢他啶高10至15倍。
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