Branch of the Institut de Veille Sanitaire in the Région Aquitaine (InVS, French Institute for Public Health Surveillance), Bordeaux, France.
Euro Surveill. 2010 Sep 16;15(37):19665.
Between December 2008 and September 2009, 11 cases of invasive meningococcal disease (IMD) group B were reported in a 20 km diameter area in the Département Landes, France. Two of them presented with purpura fulminans and one of them died. The strain responsible for this community outbreak was of the clonal complex ST-269.The incidence rate for IMD group B was 3 per 100,000 inhabitants in Landes from week 40 in 2008 to week 40 in 2009; it was the highest in France during that period. The number of cases observed was significantly higher than expected, especially in young adults (standardised incidence ratio: 23.5, p<0.001). A nightclub located in the 20 km diameter area was a possible place of transmission and a prophylaxis recommended for the staff members helped in decreasing the transmission. However, several cases notified later suggested that the bacteria circulated during several months through healthy carriers in the community. This situation prompted increased surveillance of IMD in Landes and medical practitioners were asked to remain vigilant because of the possible emergence of new cases within the following months.
2008 年 12 月至 2009 年 9 月期间，法国朗德省一个 20 公里直径的区域报告了 11 例侵袭性脑膜炎奈瑟菌 B 型（IMD）病例。其中 2 例出现暴发性紫癜，1 例死亡。导致此次社区暴发的菌株属于克隆复合体 ST-269。2008 年第 40 周至 2009 年第 40 周期间，朗德省每 10 万居民中侵袭性脑膜炎奈瑟菌 B 型的发病率为 3 例；这是同期法国最高的发病率。观察到的病例数明显高于预期，尤其是在年轻人中（标准化发病率比：23.5，p<0.001）。位于 20 公里直径区域内的一家夜总会可能是传播的场所，为工作人员推荐的预防措施有助于减少传播。然而，后来报告的几例病例表明，在接下来的几个月里，细菌通过社区中的健康携带者在传播。这种情况促使朗德省加强了对 IMD 的监测，并要求医疗保健人员保持警惕，因为在接下来的几个月里可能会出现新的病例。
