Söylemez Nihat, Demirbağ Recep, Sezen Yusuf, Yıldız Ali, Akpınar Onur
Harran Üniversitesi Tıp Fakültesi, Kardiyoloji Anabilim Dalı, Şanlıurfa, Türkiye.
Anadolu Kardiyol Derg. 2010 Oct;10(5):391-6. doi: 10.5152/akd.2010.134.
Obesity is an important risk factor of atherosclerosis and its prevalence in humans is increasing. Recent studies suggest that the leptin and adiponectin play important roles in obesity, and they are associated with complications of obesity. However, the mechanism of effects has not been outstandingly established. In this study, we studied leptin and adiponectin levels according to body mass index (BMI) and their relationship with oxidative parameters.
A total of 87 healthy individuals with BMI ≤35 kg/m² (n=29, Group 1), BMI=25-35 kg/m² (n=29, Group 2) and BMI =25 kg/m² (n=29, Group 3) were included in the cross-sectional observational study. Leptin, adiponectin levels, total antioxidant capacity (TAC) and total oxidant status (TOS) were measured. Oxidative stress index (OSI) was calculated using TAC and TOS values. Statistical analyses were performed using Chi-Square, Mann-Whitney U, one-way ANOVA, Kruskal-Wallis, Pearson correlation and multiple regression analyses tests.
Age and gender ratio were similar in the groups. The TAC level was the lowest in group 3 and the highest in group 1. The TOS level was higher in groups 2 and 3 than in group 1 (p =0.05 for both). OSI levels were similar in groups 2 and 3, and it was significantly different from the group 1 (p=0.05). The trend for leptin levels was decreasing and for antiponectin levels was increasing from group 1 to group 3. Except for other parameters, levels of leptin were independently related to the TOS (b=-1.123, 95% CI =-12.734-0.255, p=0.040), OSI (b=1.689, 95% CI=1.105-12.481, p=0.018) and waist circumference (b=-0.592, 95% CI= -0.630-0.134, p=0.003). Adiponectin had no significant relation with these parameters.
Findings of the present study reveal that leptin decreased and adiponectin increased with BMI in healthy people. These data support that these changes may be responsible in the increased TOS and OSI levels.
肥胖是动脉粥样硬化的重要危险因素，且其在人群中的患病率正在上升。最近的研究表明，瘦素和脂联素在肥胖中起重要作用，并且它们与肥胖并发症相关。然而，其作用机制尚未完全明确。在本研究中，我们根据体重指数（BMI）研究了瘦素和脂联素水平及其与氧化参数的关系。
共有87名BMI≤35kg/m²（n = 29，第1组）、BMI = 25 - 35kg/m²（n = 29，第2组）和BMI = 25kg/m²（n = 29，第3组）的健康个体纳入本横断面观察性研究。测量了瘦素、脂联素水平、总抗氧化能力（TAC）和总氧化状态（TOS）。使用TAC和TOS值计算氧化应激指数（OSI）。采用卡方检验、曼 - 惠特尼U检验、单因素方差分析、克鲁斯卡尔 - 沃利斯检验、皮尔逊相关分析和多元回归分析进行统计分析。
各组的年龄和性别比例相似。第3组的TAC水平最低，第1组最高。第2组和第3组的TOS水平高于第1组（两者p = 0.05）。第2组和第3组的OSI水平相似，且与第1组有显著差异（p = 0.05）。从第1组到第3组，瘦素水平呈下降趋势，脂联素水平呈上升趋势。除其他参数外，瘦素水平与TOS（b = -1.123，95%CI = -12.734 - 0.255，p = 0.040）、OSI（b = 1.689，95%CI = 1.105 - 12.481，p = 0.018）和腰围（b = -0.592，95%CI = -0.630 - 0.134，p = 0.003）独立相关。脂联素与这些参数无显著关系。
本研究结果表明，在健康人群中，瘦素水平随BMI降低，脂联素水平随BMI升高。这些数据支持这些变化可能是导致TOS和OSI水平升高的原因。
