Büke Barış, Topçu Hasan Onur, Engin-Üstün Yaprak, Danışman Nuri
Department of Obstetrics and Gynecology, Ege University Faculty of Medicine, İzmir, Turkey.
Department of Obstetrics and Gynecology, Zekai Tahir Burak Women's Health Education and Research Hospital, Ankara, Turkey.
J Turk Ger Gynecol Assoc. 2014 Aug 8;15(3):173-6. doi: 10.5152/jtgga.2014.13130. eCollection 2014.
The aim of this study was to compare serum maternal adiponectin concentrations in pregnant women with isolated intrauterine growth retardation (IUGR) and in pregnant women with IUGR concomitant with pre-eclampsia (IUGRcwPE).
Thirty patients with isolated IUGR (group 1), 20 patients with IUGRcwPE (group 2), and 30 healthy controls (group 3) between age 18-40 were included into the study. Venous blood samples of those patients were obtained in the starving state. Adiponectin concentrations were measured by enzyme-linked immunosorbent assay in serum obtained after centrifugation. To find the differences between the groups, student t-test and one-way ANOVA statistical methods were used.
There were no differences between the groups in terms of age, body mass index, gestational age, and parity (p>0.05). The values of amniotic fluid index (p<0.001) and weight gained during pregnancy (p=0.017) were significantly different when compared among the three groups. The mean concentrations of adiponectin were 94.041 pg/mL in the IUGR group, 55.717 pg/mL in the IUGRcwPE group, and 51.831 pg/mL in the control group. Both of the differences between the IUGR and IUGRcwPE groups (p value; <0.05) and IUGR and control groups were statistically significant (p value; <0.001). However, there were no significant differences between the IUGRcwPE group and control group (p>0.05).
We found that IUGR increased maternal serum adiponectin concentrations; however, this rise does not occur in pregnant women with IUGRcwPE.
本研究旨在比较孤立性胎儿宫内生长受限（IUGR）孕妇与合并子痫前期的胎儿宫内生长受限（IUGRcwPE）孕妇血清中母体脂联素浓度。
本研究纳入了30例孤立性IUGR患者（第1组）、20例IUGRcwPE患者（第2组）和30例年龄在18至40岁之间的健康对照者（第3组）。在空腹状态下采集这些患者的静脉血样本。通过酶联免疫吸附测定法测量离心后获得的血清中的脂联素浓度。为了找出各组之间的差异，使用了学生t检验和单因素方差分析统计方法。
各组在年龄、体重指数、孕周和产次方面无差异（p>0.05）。三组间羊水指数（p<0.001）和孕期体重增加量（p=0.017）的值有显著差异。IUGR组脂联素平均浓度为94.041 pg/mL，IUGRcwPE组为55.717 pg/mL，对照组为51.831 pg/mL。IUGR组与IUGRcwPE组之间（p值；<0.05）以及IUGR组与对照组之间的差异均具有统计学意义（p值；<0.001）。然而，IUGRcwPE组与对照组之间无显著差异（p>0.05）。
我们发现IUGR会增加母体血清脂联素浓度；然而，这种升高在IUGRcwPE孕妇中并未出现。
