Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, Bethesda, Maryland 20892, USA.
Cancer Epidemiol Biomarkers Prev. 2010 Oct;19(10):2680-4. doi: 10.1158/1055-9965.EPI-10-0585.
Other than male sex, family history, advanced age, and race, risk factors for chronic lymphocytic leukemia and small lymphocytic lymphoma (CLL/SLL) are unknown. Very few studies have investigated diet in relation to these leukemias, and no consistent associations are known.
Using two large prospective population-based studies, we evaluated the relationship between diet and CLL/SLL risk. Among 525,982 men and women free of cancer at enrollment, we identified 1,129 incident CLL/SLL cases during 11.2 years of follow-up.
We found no associations between total fat, saturated fat, fiber, red meat, processed meat, fruit, or vegetable intake and risk of CLL/SLL. We noted a suggestive positive association between body mass index and CLL/SLL (hazard ratio, 1.30; 95% confidence interval, 0.99-1.36).
We did not find any associations between food or nutrient intake and CLL/SLL.
Our large prospective study indicates that diet may not play a role in CLL/SLL development.
除了男性性别、家族史、高龄和种族之外，慢性淋巴细胞白血病和小淋巴细胞淋巴瘤（CLL/SLL）的风险因素尚不清楚。很少有研究调查饮食与这些白血病之间的关系，也没有已知的一致关联。
我们使用两项大型前瞻性基于人群的研究，评估了饮食与 CLL/SLL 风险之间的关系。在 525982 名入组时无癌症的男性和女性中，我们在 11.2 年的随访期间确定了 1129 例 CLL/SLL 新发病例。
我们没有发现总脂肪、饱和脂肪、纤维、红色肉类、加工肉类、水果或蔬菜摄入与 CLL/SLL 风险之间存在关联。我们注意到体重指数与 CLL/SLL 之间存在提示性的正相关关系（风险比，1.30；95%置信区间，0.99-1.36）。
我们没有发现食物或营养素摄入与 CLL/SLL 之间存在任何关联。
我们的大型前瞻性研究表明，饮食可能在 CLL/SLL 的发展中不起作用。
