饮食因素与慢性淋巴细胞白血病和小淋巴细胞淋巴瘤风险：两项前瞻性研究的 pooled 分析。
Dietary factors and risk of chronic lymphocytic leukemia and small lymphocytic lymphoma: a pooled analysis of two prospective studies.
机构信息
Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, Bethesda, Maryland 20892, USA.
出版信息
Cancer Epidemiol Biomarkers Prev. 2010 Oct;19(10):2680-4. doi: 10.1158/1055-9965.EPI-10-0585.
Abstract
BACKGROUND
Other than male sex, family history, advanced age, and race, risk factors for chronic lymphocytic leukemia and small lymphocytic lymphoma (CLL/SLL) are unknown. Very few studies have investigated diet in relation to these leukemias, and no consistent associations are known.
METHODS
Using two large prospective population-based studies, we evaluated the relationship between diet and CLL/SLL risk. Among 525,982 men and women free of cancer at enrollment, we identified 1,129 incident CLL/SLL cases during 11.2 years of follow-up.
RESULTS
We found no associations between total fat, saturated fat, fiber, red meat, processed meat, fruit, or vegetable intake and risk of CLL/SLL. We noted a suggestive positive association between body mass index and CLL/SLL (hazard ratio, 1.30; 95% confidence interval, 0.99-1.36).
CONCLUSION
We did not find any associations between food or nutrient intake and CLL/SLL.
IMPACT
Our large prospective study indicates that diet may not play a role in CLL/SLL development.
摘要
背景
除了男性性别、家族史、高龄和种族之外，慢性淋巴细胞白血病和小淋巴细胞淋巴瘤（CLL/SLL）的风险因素尚不清楚。很少有研究调查饮食与这些白血病之间的关系，也没有已知的一致关联。
方法
我们使用两项大型前瞻性基于人群的研究，评估了饮食与 CLL/SLL 风险之间的关系。在 525982 名入组时无癌症的男性和女性中，我们在 11.2 年的随访期间确定了 1129 例 CLL/SLL 新发病例。
结果
我们没有发现总脂肪、饱和脂肪、纤维、红色肉类、加工肉类、水果或蔬菜摄入与 CLL/SLL 风险之间存在关联。我们注意到体重指数与 CLL/SLL 之间存在提示性的正相关关系（风险比，1.30；95%置信区间，0.99-1.36）。
结论
我们没有发现食物或营养素摄入与 CLL/SLL 之间存在任何关联。
影响
我们的大型前瞻性研究表明，饮食可能在 CLL/SLL 的发展中不起作用。
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