Zheng Tongzhang, Holford Theodore R, Leaderer Brian, Zhang Yawei, Zahm Shelia Hoar, Flynn Stuart, Tallini Giovanni, Zhang Bing, Zhou Kaiyong, Owens Patricia H, Lan Qing, Rothman Nathaniel, Boyle Peter
Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, CT, USA.
Am J Epidemiol. 2004 Mar 1;159(5):454-66. doi: 10.1093/aje/kwh067.
A population-based case-control study (601 cases and 717 controls) was conducted in 1995-2001 among Connecticut women to evaluate the relation between diet and nutrient intakes and the risk of non-Hodgkin's lymphoma (NHL). When the highest quartile of intake was compared with the lowest, the authors found an increased risk of NHL associated with animal protein (odds ratio = 1.7, 95% confidence interval: 1.2, 2.4) and saturated fat (odds ratio = 1.9, 95% confidence interval: 1.1, 2.3) but a reduced risk for polyunsaturated fat (odds ratio = 0.6, 95% confidence interval: 0.4, 0.9) and no relation for vegetable protein and monounsaturated fat. An increased risk was also observed for higher intakes of retinol, eggs, and dairy products. On the other hand, a reduced risk was found for higher intakes of dietary fiber and for several fruit and vegetable items. Risk of NHL associated with diet and nutrient intakes appeared to vary based on NHL subtype. An association between dietary intake and NHL risk is biologically plausible because diets high in protein and fat may lead to altered immunocompetence, resulting in an increased risk of NHL. The antioxidant or inhibiting nitrosation reaction properties of vegetables and fruits may result in a reduced risk. Further investigation of the role of dietary intakes on the risk of NHL is warranted.
1995年至2001年期间，在康涅狄格州的女性中开展了一项基于人群的病例对照研究（601例病例和717名对照），以评估饮食和营养摄入与非霍奇金淋巴瘤（NHL）风险之间的关系。当将摄入量最高的四分位数与最低的四分位数进行比较时，作者发现NHL风险增加与动物蛋白（比值比=1.7，95%置信区间：1.2，2.4）和饱和脂肪（比值比=1.9，95%置信区间：1.1，2.3）有关，但与多不饱和脂肪风险降低（比值比=0.6，95%置信区间：0.4，0.9）有关，而与植物蛋白和单不饱和脂肪无关。还观察到视黄醇、鸡蛋和乳制品摄入量较高时风险增加。另一方面，膳食纤维以及几种水果和蔬菜摄入量较高时风险降低。与饮食和营养摄入相关的NHL风险似乎因NHL亚型而异。饮食摄入与NHL风险之间的关联在生物学上是合理的，因为高蛋白和高脂肪饮食可能导致免疫能力改变，从而增加NHL风险。蔬菜和水果的抗氧化或抑制亚硝化反应特性可能导致风险降低。有必要进一步研究饮食摄入在NHL风险中的作用。
