Evans H J
Medical Research Council Human Genetics Unit, Western General Hospital, Edinburgh, UK.
Digestion. 1990;47 Suppl 1:45-8. doi: 10.1159/000200515.
Omeprazole has been subjected to an unusually extensive range of genotoxicity tests ranging from mutational assays in bacteria (e.g. Ames test), mutation and chromosome damage tests on mammalian cells in vitro, chromosome damage tests in mouse bone marrow and erythroid precursor cells exposed in vivo, and DNA damage assays in the nuclei of liver cells of rats exposed to omeprazole in vivo. The conclusions from these studies were uniformly negative. Details of the tests are summarized in this review.
奥美拉唑已经接受了异常广泛的遗传毒性测试，范围从细菌中的突变试验（如艾姆斯试验）、体外哺乳动物细胞的突变和染色体损伤试验、体内暴露于奥美拉唑的小鼠骨髓和红细胞前体细胞的染色体损伤试验，以及体内暴露于奥美拉唑的大鼠肝细胞细胞核中的DNA损伤试验。这些研究的结论均为阴性。测试细节在本综述中进行了总结。
